老年非小细胞肺癌患者化疗前后生存质量变化及其影响因素分析  

Quality of life and its influencing factors in elderly patients with non-small cell lung cancer before and after chemotherapy

作　　者：陈玉芬[1] 杨春茂[1] 李燕舞[1] CHEN Yu-fen;YANG Chun-mao;LI Yan-wu(Three Disease Areas,Department of Respiratory,Third People's Hospital of Chengdu,Chengdu 610031,China)

机构地区：[1]成都市第三人民医院呼吸科三病区

出　　处：《中国医学前沿杂志（电子版）》2019年第11期106-109,共4页Chinese Journal of the Frontiers of Medical Science(Electronic Version)

摘　　要：目的分析老年非小细胞肺癌(non-small cell lung cancer,NSCLC)患者化疗前后生存质量变化及其影响因素。方法选取2017年1月至2018年8月于本院行化疗的51例Ⅲ~Ⅳ期老年NSCLC患者为研究对象,采用肺癌生存质量测定量表(functional assessment of cancer therapy-lung,FACT-L)中文版(V4.0)评估患者化疗前后生存质量,并分析患者化疗后生存质量的影响因素。结果全部患者化疗后4周FACT-L中文版(V4.0)中的生理状况、社会家庭状况、情感状况、功能状况、肺癌特异模块等各领域的评分和总分均显著高于化疗前1 d(均P<0.05)。男性、年龄<70岁、与家人同住、平均月收入>3000元、体力状况(performance status,PS)评分为0~1分、无合并症、病理分期为Ⅲ期、近期疗效为有效者化疗后4周FACT-L中文版(V4.0)总分均显著高于女性、年龄≥70岁、独居、平均月收入<1500元、PS评分为2分、2种及以上合并症、病理分期为Ⅳ期、近期疗效为无效者(均P<0.05)。多元线性回归分析结果表明,年龄、平均月收入、近期疗效均为老年NSCLC患者化疗后生存质量的独立影响因素(均P<0.05)。结论化疗能显著改善Ⅲ~Ⅳ期老年NSCLC患者的生存质量,超高龄、平均月收入低下、近期疗效无效者化疗后短期生存质量较差。Objective To analyze the quality of life and its influencing factors in elderly patients with non-small cell lung cancer(NSCLC)before and after chemotherapy.Method A total of 51 cases of elderly patients with stage Ⅲ~Ⅳ NSCLC underwent chemotherapy in our hospital from January 2017 to August 2018 were enrolled for the study.The patients'quality of life before and after chemotherapy was assessed by Chinese version of functional assessment of cancer therapy-lung(FACT-L)(V4.0),and the influencing factors of quality of life after chemotherapy were screened.Result The scores of physiological status,social and family status,emotional status,functional status,lung cancer specific module of Chineses version FACT-L(V4.0)and total score of all patients at 4 weeks after chemotherapy were significantly higher than those at 1 d before chemotherapy(all P<0.05).The total score of FACT-L(V4.0)in patients with male,aged<70 years old,living with family,average monthly income>3000 yuan,PS score 0~1 point,no complications,pathological stage Ⅲ,short-term efficacy at 4 weeks after chemotherapy were significantly higher than those with female,age≥70 years old,living alone,average monthly income<1500 yuan,PS score 2 points,two or more complications,pathological stage Ⅳ and short-term invalid(all P<0.05).Multivariate linear regression analysis showed that age,average monthly income and short-term efficacy were the independent influencing factors of quality of life after chemotherapy(all P<0.05).Conclusion Chemotherapy can significantly improve the quality of life of elderly patients with stage Ⅲ~Ⅳ NSCLC.The shortterm quality of life after chemo therapy of patients with super-elderly,low average monthly income and short-term invalid is poor.

关 键 词：生存质量 非小细胞肺癌 化疗 因素分析 老年 

分 类 号：R73[医药卫生—肿瘤]