肠脂肪酸结合蛋白及D-乳酸与急性肠梗阻预后的关系  

Relationship between intestinal fatty acid binding protein, D-lactic acid, and the prognosis of acute intestinal obstruction

作　　者：黄元林 陈建洪 HUANG Yuan-lin;CHEN Jian-hong(Emergency Department,the 95th Hospital of the Chinese People's Liberation Army,Putian 351100,Fujian,CHINA)

机构地区：[1]中国人民解放军第95医院急诊科

出　　处：《海南医学》2019年第22期2964-2966,共3页Hainan Medical Journal

摘　　要：目的探讨肠脂肪酸结合蛋白(IFABP)及D-乳酸与急性肠梗阻预后的关系。方法选取2016年2月至2019年2月期间中国人民解放军第九五医院急诊科收治的60例急性肠梗阻患者作为观察组,60例在本院接受健康体检的健康人群作为对照组,检测并比较两组受检者的血清IFABP及D-乳酸水平;根据术后诊断将观察组患者分为单纯性肠梗阻组31例与绞窄性肠梗阻组29例,比较其入院时的血清IFABP及D-乳酸水平。结果观察组患者入院时的IFABP及D-乳酸水平分别为(982.2±83.3)ng/mL、(326.1±98.2)μg/L,明显高于对照组的(160.2±76.2)ng/mL、(219.4±69.3)μg/L,差异均具有统计学意义(P<0.05);单纯性肠梗阻组患者入院时的IFABP、D-乳酸水平分别为(732.6±72.6)ng/mL、(285.3±76.4)μg/L,明显低于绞窄性肠梗阻组患者的(1232.4±122.1)ng/mL、(402.6±86.7)μg/L,差异均具有统计学意义(P<0.05)。结论IFABP、D-乳酸可作为肠梗阻诊断的辅助检测指标,临床上上述两项指标明显增高的患者应考虑绞窄性肠梗阻的可能;此外,治疗过程中可利用上述两项指标的动态变化来了解患者的疗效,并用于预后评估。Objective To analyze the relationship between intestinal fatty acid binding protein(IFABP),D-lactic acid,and the prognosis of acute intestinal obstruction.Methods Sixty patients with acute bowel obstruction(ABO)from February 2016 to February 2019 were enrolled into the observation group,and 60 healthy people were selected into the control group.Then the serum IFABP and D-lactic acid were compared between the two groups.Then 29 patients in the observation group were diagnosed as strangulated intestinal obstruction,and the other 31 patients were diagnosed as simple intestinal obstruction.Serum IFABP and D-lactic acid were compared between the patients with strangulated intestinal obstruction and simple intestinal obstruction.Results IFABP,D-lactic acid were(982.2±83.3)ng/mL,(326.1±98.2)μg/L in the observation group,significantly higher than(160.2±76.2)ng/mL,(219.4±69.3)μg/L in the control group(P<0.05).IFABP,D-lactic acid were(732.6±72.6)ng/mL,(285.3±76.4)μg/L in the patients with simple intestinal obstruction at the admission time,significantly lower than(1232.4±122.1)ng/mL,(402.6±86.7)μg/L in the patients with strangulated intestinal obstruction(P<0.05).Conclusion IFABP and D-lactic acid can be used as auxiliary diagnostic indicators for intestinal obstruction.The possibility of strangulated intestinal obstruction should be taken into account in patients with significantly increased IFABP and D-lactic acid.In addition,in the course of treatment,the dynamic changes of the above two indicators could be used to understand the curative effect of patients and to evaluate the prognosis.

关 键 词：肠脂肪酸结合蛋白 D-乳酸 检测 急性肠梗阻 预后 

分 类 号：R574.2[医药卫生—消化系统]