甲醛在变应性鼻炎发病中的作用及机制研究  

The role and mechanism of formaldehyde in the path ogenesis of allergic rhinitis

作　　者：雷旭艳[1] 唐隽[1] 王凯[1] Lei Xuyan;Tang Jun;Wang Kai(Allergen Laboratory of ENT,the First People's Hospital of Foshan,Guangdong 528000,China)

机构地区：[1]广东省佛山市第一人民医院耳鼻喉科过敏原实验室

出　　处：《实用医技杂志》2019年第10期1235-1237,共3页Journal of Practical Medical Techniques

基　　金：广东省自然科学基金(2015A030313771);广东省佛山市卫生和计生局医学科研课题(20170063)

摘　　要：目的探究甲醛与变应性鼻炎的关系及其作用机制,旨在为临床上更好地控制变应性鼻炎的发病提供依据。方法笔者以2016年5月至2017年4月来佛山市第一人民医院的194例过敏性鼻炎患者作为研究对象,再对上述194例患者中进行流行病学调查后发现接触过甲醛者92例,未接触者102例,上述患者入院后分别采用免疫球蛋白E(IgE)测定试剂(荧光免疫法);甲醛试剂(荧光免疫法),该试剂盒由对上述患者的IgE和K80进行测定。结果试验组患者其IgE阳性为78例,14例出现阴性结果,数据显示有45例对照组中的患者在检测中出现IgE阳性,57例患者出现了阴性结果,这2组做比较有很大的差距,差异有统计学意义(χ^2=6.99,P=0.04);在试验组中有高达82例患者出现了K80阳性,10例患者出现了阴性的结果,而在对照组中,有42例患者表现为K80阳性,60例患者出现了阴性的结果,2组比较差异有统计学意义(χ^2=9.02,P=0.02),检测指标中D1、D2、I6、W6等2组进行比较,差异无统计学意义(P>0.05)。结论甲醛在AR发病过程中是主要的辅助因素或触发因素,主要侵袭人体的免疫系统,使机体失去抵抗力,对刺激因子失去防御功能,对于研究甲醛的吸入进而引起AR的相关机制以及临床应对有积极作用。Objective To explore the relationship between formaldehyde and allergic rhinitis and its mechanism of action,aiming to provide a basis for better control of the pathogenesis of allergic rhinitis in clinical practice.Methods The method is to come to Foshan City from May 2016 to April 2017.A total of 194 patients with allergic rhinitis in a People′s Hospital were included in the study.In an epidemiological survey of 194 patients,92 cases of exposure to formaldehyde were found,and 102 cases were not contacted.The above patients were treated with immunoglobulin after admission.E(IgE)assay kit,formaldehyde reagent,fluorescent immunoassay the kit was determined from IgE and K80 of the above patients.Results In the experimental group,the IgE was positive in 78 cases,and 14 cases had negative results.According to the data,45 patients in the control group showed IgE positive in the test,and 57 patients had negative results.A large gap was statistically significant.The obtainedχ^2=6.99,P=0.04;in the experimental group,up to82 patients developed K80 positive,and 10 patients showed negative results.In the control group,42 patients showed positive K80 and 60 patients had negative results.There was also a very large difference between the two groups.The difference was statistically significant.The obtainedχ^2=9.02,P=0.02;D1,D2,I6,W6 and other two groups were compared,the difference was not significant,no statistical significance(P>0.05);Conclusion Formaldehyde is the main cause in the pathogenesis of AR Auxiliary factors or triggers,Factors,mainly invading the body′s immune system,causing the body to lose its resistance,loss of defense function to stimulating factors,and have a positive effect on the study of formaldehyde inhalation and the related mechanisms of AR and clinical response.

关 键 词：甲醛 鼻炎 变应性 季节性 发病率 

分 类 号：R73[医药卫生—肿瘤]