神经突触核蛋白-γ、骨形态发生蛋白2、基质金属蛋白酶9在口腔颌面部鳞癌中的表达情况及相关性分析  

Expression of synuclein-γ, bone morphogenetic protein-2 and matrix metalloproteinase-9 in oral and maxillofacial squamous cell carcinoma and their correlation analysis

作　　者：齐晓宇 QI Xiao-yu(Department of Ophthalmology and Otorhinolaryngology,Iron and Coal General Hospital of Liaoning Health Industry Group,Liaoning Province,Tieling 112700,China)

机构地区：[1]辽宁省健康产业集团铁煤总医院五官科

出　　处：《中国当代医药》2019年第32期144-147,共4页China Modern Medicine

摘　　要：目的分析神经突触核蛋白-γ(SNCG)、骨形态发生蛋白2(BMP-2)、基质金属蛋白酶9(MMP-9)在口腔颌面部鳞癌中的表达情况及相关性。方法选取2016年1月21日~2017年1月21日我院存档的70例口腔颌面部鳞癌组织蜡块标本作为肿瘤组织,另选择70例癌旁组织与70例正常组织进行参照。依据肿瘤细胞的分化程度,将70例肿瘤组织标本分为高分化组(15例),中分化组(33例)及低分化组(22例)。依据是否出现淋巴结转移情况,将70例肿瘤组织标本分为淋巴结转移(30例)及淋巴结未转移(40例)。比较三组不同组织部位标本中的SNCG、BMP-2、MMP-9表达情况;比较不同分化程度肿瘤组织中SNCG、BMP-2、MMP-9的表达阳性率;分析淋巴结转移对肿瘤组织中SNCG、BMP-2、MMP-9表达阳性率的影响;分析SNCG、BMP-2、MMP-9三者之间的相关性。结果肿瘤组织中的SNCG、MMP-9的阳性率高于癌旁组织和正常组织,差异有统计学意义(P<0.05);癌旁组织与正常组织的SNCG、MMP-9阳性率比较,差异无统计学意义(P>0.05)。肿瘤组织和癌旁组织中的BMP-2的阳性率高于正常组织,差异有统计学意义(P<0.05);癌旁组织与肿瘤组织的BMP-2阳性率比较,差异无统计学意义(P>0.05)。高、中、低分化组肿瘤组织中的BMP-2与MMP-9阳性率比较,差异无统计学意义(P>0.05);高分化组肿瘤组织中的SNCG阳性率低于低、中分化组,差异有统计学意义(P<0.05);低、中分化组肿瘤组织中的SNCG阳性率比较,差异无统计学意义(P>0.05)。出现淋巴结转移组织中的SNCG、MMP-9阳性率高于淋巴结未转移组织,差异有统计学意义(P<0.05)。SNCG与BMP-2蛋白成正相关性(r=0.420,P<0.05),BMP-2与MMP-9成正相关性(r=0.390,P<0.05),SNCG与MMP-9成正相关性(r=0.561,P<0.05)。结论在口腔颌面部鳞癌中,SNCG、BMP-2、MMP-9三者互成正相关性,具有高表达特征,可作为该类肿瘤疾病的常用检测指标。Objective To analyze the expression and correlation of synuclein-γ(SNCG),bone morphogenetic protein-2(BMP-2)and matrix metalloproteinase-9(MMP-9)in oral and maxillofacial squamous cell carcinoma.Methods From January 21,2016 to January 21,2017,70 cases of oral and maxillofacial squamous cell carcinoma wax specimens archived in our hospital were selected as tumor tissues.Another 70 cases of adjacent tissues and 70 normal tissues were selected for reference.According to the degree of differentiation of tumor cells,70 tumor tissue samples were divided into high differentiation group(15 cases),medium differentiation group(33 cases)and low differentiation group(22 cases).According to the presence or absence of lymph node metastasis,70 tumor tissue samples were divided into lymph node metastasis(30 cases)and no lymph node metastasis(40 cases).The expression of SNCG,BMP-2 and MMP-9 in three different tissues were compared.The positive expression rates of SNCG,BMP-2 and MMP-9 in tumor tissues with different differentiation degrees were compared.The effect of lymph node metastasis on the positive expression rates of SNCG,BMP-2 and MMP-9 in tumor tissues was analyzed.The correlation among SNCG,BMP-2 and MMP-9 were analyzed.Results The positive rates of SNCG and MMP-9 in tumor tissues were higher than those in adjacent tissues and normal tissues,the differences were statistically significant(P<0.05).There was no significant difference in the positive rate of SNCG and MMP-9 between the adjacent tissues and normal tissues(P>0.05).The positive rate of BMP-2 in tumor tissues and adjacent tissues were higher than that in normal tissues,and the differences were statistically significant(P<0.05).There was no significant difference in the positive rate of BMP-2 between the adjacent tissues and tumor tissues(P>0.05).The positive rates of BMP-2 and MMP-9 in the tumor tissues of the high,medium and low differentiation groups were not statistically significant(P>0.05).The positive rate of SNCG in tumor tissues in the high differentiate

关 键 词：口腔颌面部 鳞癌 神经突触核蛋白-γ 骨形态发生蛋白2 基质金属蛋白酶9 表达 相关性 

分 类 号：R739.81[医药卫生—肿瘤]