基于生物信息数据库分析钠碘同向转运体编码基因SLC5A5在甲状腺癌中的表达及临床意义  

Expression and clinical significance of SLC5A5 gene of sodium/iodide symporter in thyroid carcinoma based on the biological information database

作　　者：佟君羽 乔婷婷 吕中伟[1] 李丹[1] Tong Junyu;Qiao Tingting;Lyu Zhongwei;Li Dan(Department of Nuclear Medicine,Tenth People′s Hospital of Tongji University,Shanghai 200072,China)

机构地区：[1]同济大学附属第十人民医院核医学科,上海200072

出　　处：《中华核医学与分子影像杂志》2019年第11期670-674,共5页Chinese Journal of Nuclear Medicine and Molecular Imaging

摘　　要：目的研究钠碘同向转运体(NIS)编码基因溶质载体家族成员5(SLC5A5)在甲状腺癌中的表达情况及其在甲状腺癌中的临床意义。方法运用肿瘤基因组图谱(TCGA)数据库获取SLC5A5基因在甲状腺癌组织和正常甲状腺组织中的表达信息,将结果进行两独立样本t检验并绘制散点图。在癌症多组学和临床数据库LinkedOmics平台进行SLC5A5 mRNA表达水平与甲状腺癌临床特征之间的关系分析,采取Kruskal-Wallis检验或Wilcoxon检验比较差异。结果TCGA数据库分析结果示:与正常甲状腺组织相比,甲状腺癌的SLC5A5 mRNA表达量降低(3.301±0.087与1.419±0.049;t=12.66,P<0.01)。甲状腺癌SLC5A5 mRNA表达情况在不同人种中存在差异(χ2=0.300,P<0.05),且随着病理分期(Ⅰ、Ⅱ、Ⅲ、Ⅳ)及病理T、N、M分期的逐步升高,表达呈逐渐降低趋势(χ2值:0.114、0.215,z值:-0.345、-0.102,均P<0.05)。结论在甲状腺癌中,SLC5A5 mRNA的表达水平与临床特征存在一定程度的联系,SLC5A5 mRNA有望成为评估和预测甲状腺癌发展的生物标志物。Objective To analyze the expression and clinical significance of solute carrier family 5 member 5(SLC5A5),the coding gene of sodium/iodide symporter(NIS),in thyroid carcinoma.Methods The messenger RNA(mRNA)expression of SLC5A5 in thyroid carcinoma and normal thyroid tissues from The Cancer Genome Atlas(TCGA)was compared using independent-sample t test and results were shown in one scatter plot.The relation between clinical features of thyroid carcinoma and the changes of SLC5A5 mRNA was analyzed on LinkedOmics using Kruskal-Wallis test or Wilcoxon test.Results Data from TCGA showed that the SLC5A5 mRNA expression in thyroid carcinoma(1.419±0.049)was significantly reduced compared with that in normal thyroid tissues(3.301±0.087;t=12.66,P<0.01).The expression of SLC5A5 mRNA in thyroid carcinoma is affected by ethnicity(χ2=0.300,P<0.05).Moreover,the expression of SLC5A5 mRNA were decreased with the increase of pathologic grading(Ⅰ,Ⅱ,Ⅲ,Ⅳ)and T,N,M stages(χ2 values:0.114,0.215,z values:-0.345,-0.102,all P<0.05).Conclusions The expression level of SLC5A5 mRNA is associated with clinical characteristic of thyroid carcinoma.SLC5A5 mRNA has the potential to become one candidate biomarker to assess disease and predict the development of thyroid carcinoma.

关 键 词：甲状腺肿瘤 钠/碘转运体 基因表达 数据库 核酸 

分 类 号：R73[医药卫生—肿瘤]