阿帕替尼降低平滑肌肉瘤瘤体微血管密度的病例验证  

Apatinib reduces microvascular density in leiomyosarcoma:a case report

作　　者：季艳霞[1] 康振桥[1] 赵艳争 杨慧敏 王忠瑜 郭青 JI Yanxia;KANG Zhenqiao;ZHAO Yanzheng;YANG Huimin;WANG Zhongyu;GUO Qing(Oncology Department,Handan Central Hospital,Handan,Hebei 056000,China)

机构地区：[1]邯郸市中心医院肿瘤科

出　　处：《安徽医药》2019年第12期2501-2503,I0003,共4页Anhui Medical and Pharmaceutical Journal

基　　金：北京医卫健康公益基金会“医学科学研究基金”项目(YWJKJJHKYJJ-F1169B)

摘　　要：目的观察阿帕替尼治疗前后瘤体微血管密度的变化。方法选择2016年5月邯郸市中心医院收治的1例平滑肌肉瘤病人,第1次根治手术组织行免疫组织化学染色,术后行6周期化疗,腹部CT提示复发后口服阿帕替尼250 mg,每天1次,治疗5.5个月再次复发后行第2次手术取病理,组织免疫组织化学CD34染色,观察阿帕替尼治疗前后瘤体微血管密度的变化情况。结果阿帕替尼治疗平滑肌肉瘤,治疗后瘤体微血管密度显著降低,腹部CT提示4个月后腹腔肿瘤较前缩小。结论阿帕替尼可降低平滑肌肉瘤微血管密度,从而抑制肿瘤生长。Objective To observe changes in microvessel density after treatment with apatinib in leiomyosarcoma.Methods We received a patient with leiomyosarcoma who was treated in Handan Central Hospital in May 2016.The first radical operation was performed by immunohistochemical staining,and 6 cycles of chemotherapy were performed after surgery.After abdominal recur rence,oral apatinib(250 mg,qd,po)was treated.Recurrence after 5.5 months,the second operation was performed for pathology,and tissue immunohistochemical staining for CD34 was performed to observe the changes of tumor microvessel density after treat ment with apatinib.Results Apatinib was used to treat leiomyosarcoma,and the microvessel density of the tumor was significantly reduced after treatment,Abdominal CT indicated that abdominal lesions was smaller after 4 months.Conclusion Apatinib reduces microvascular density in leiomyosarcoma,and inhibits tumor growth.

关 键 词：平滑肌肉瘤 阿帕替尼 微血管 内皮生长因子 结肠成像 计算机体层摄影 微血管密度 

分 类 号：R73[医药卫生—肿瘤]