血清胃蛋白酶原和胃泌素17在胃癌及萎缩性胃炎中的诊断价值研究  

Study on the diagnostic value of serum pepsinogen and gastrin-17 in gastric cancer and atrophic gastritis

作　　者：安云飞[1] 丁霏 蔡蓓[1] 赵文玲 胡静[1] 黄卓春[1] 李立新[1] An Yunfei;Ding Fei;Cai Bei;Zhao Wenling;Hu Jing;Huang Zhuochun;Li Lixin(Department of Laboratory Medicine,West China Hospital of Sichuan University,Chengdu 610041,China)

机构地区：[1]四川大学华西医院实验医学科

出　　处：《中华临床实验室管理电子杂志》2019年第4期214-218,共5页Chinese Journal of Clinical Laboratory Management(Electronic Edition）

摘　　要：目的探讨血清中胃蛋白酶原(pepsinogen,PG)和胃泌素-17(gastrin-17,G-17)在非萎缩性胃炎、萎缩性胃炎及胃癌中的水平变化及临床价值.方法应用酶联免疫吸附试验检测37例非萎缩性胃炎、37例萎缩性胃炎和65例胃癌患者血清胃蛋白酶原Ⅰ(PGⅠ)、胃蛋白酶原Ⅱ(PGⅡ)、G-17的水平和PGⅠ/PGⅡ的比值(PGR).结果萎缩性胃炎组的PGⅠ水平和PGR值较非萎缩性胃炎组明显降低(P<0.05);胃癌组的PGⅠ水平和PGR值较非萎缩性胃炎组及萎缩性胃炎组明显降低(P<0.05);胃癌组的PGⅡ水平较非萎缩性胃炎组明显升高(P<0.05);胃癌组的G-17水平较萎缩性胃炎和非萎缩性胃炎组明显升高(P<0.05);胃癌组胃窦癌比胃体癌组者的血清G-17水平明显升高(P<0.05).结论胃蛋白酶原和胃泌素可以作为筛查萎缩性胃炎和胃癌的血清学指标,血清胃泌素-17对于鉴别胃窦和胃体癌有较大的临床价值.Objective To investigate the level changes and clinical value of serum pepsinogen(PG)and gastrin-17(Gastrin-17)in non-atrophic gastritis,atrophic gastritis and gastric cancer.Method PepsinogenⅠ(PGⅠ),pepsinogenⅡ(PGⅡ),gastrin-17(G-17)and the PGⅠ/PGⅡ(PGR)levels were measured in 37 patients with non-atrophic gastritis,37 patients with atrophic gastritis and 65 patients with gastric cancer by enzyme-linked immunosorbent assay.Results The PGⅠand PGR in the atrophic gastritis group were significantly lower than those in the non-atrophic gastritis group(P<0.05).The PGⅠand PGR levels in the gastric cancer group were significantly lower than those in non-atrophic gastritis group and atrophic gastritis group(P<0.05).The level of PGⅡin the gastric cancer group was significantly higher than that in the non-atrophic gastritis group(P<0.05).The G-17 in the gastric cancer group was significantly higher than that that in the atrophic gastritis and non-atrophic gastritis group(P<0.05).The G-17 in the gastric antrum cancer group was significantly higher than that in the gastric body cancer group(P<0.05).Conclusions Pepsinogen and gastrin can be used as serological markers for screening atrophic gastritis and gastric cancer.Serum gastrin-17 has great clinical value in distinguishing gastric antrum and gastric body cancer.

关 键 词：胃蛋白酶原 胃肿瘤 萎缩性胃炎 胃泌素-17 

分 类 号：R73[医药卫生—肿瘤]