广东紫珠中的苯丙素类化合物及其抗菌活性  

Phenylpropanoid compounds isolated from Callicarpa kwangtungensis and antibacterial activity research

作　　者：杨智颖 袁欢[1] 周莹[2] 林朝展[1] 彭光天[1] 吴爱芝[1] 祝晨蔯[1] YANG Zhi-ying;YUAN Huan;ZHOU Ying;LIN Chao-zhan;PENG Guang-tian;WU Ai-zhi;ZHU Chen-chen(School of Pharmaceutical,Sciences,Guangzhou University of Chinese Medicine;School of Basic Medical Science,Guangzhou University of Chinese Medicine,Guangzhou 510006,China)

机构地区：[1]广州中医药大学中药学院 [2]广州中医药大学基础医学院,广州510006

出　　处：《天然产物研究与开发》2019年第11期1928-1933,共6页Natural Product Research and Development

基　　金：国家自然科学基金(81603269);广东省自然科学基金(2015A030310491)

摘　　要：采用多种色谱技术从岭南常用药材广东紫珠(Callicarpa kwangtungensis)地上部分醇提物中分离得到10个苯丙素类化合物,通过波谱分析和文献数据对照,将其分别鉴定为3-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-2-[4-(3-hydroxy-1-(E)-propenyl)-2,6-dimethoxyphenoxy]-propyl-β-D-glucopyranoside(1)、peiioside A(2)、syringalide A 3′-α-L-rhanmnopyranoside(3)、parvifloroside A(4)、leucosceptoside B(5)、alyssonoside(6)、longissimoside B(7)、acteoside(8)、forsythoside B(9)和poliumoside(10)。其中,化合物1为首次从马鞭草科植物中分离得到,化合物4为首次从紫珠属植物中分离得到,化合物2、5和7均为首次从该植物中分离得到。抑菌实验结果表明,广东紫珠中4个含量较为丰富的苯丙素类化合物6、8、9和10对金黄色葡萄球菌、大肠杆菌和绿脓杆菌具有一定程度的抑制活性。研究结果为广东紫珠在抑菌方面的临床应用提供了参考依据。Ten phenylpropanoid compounds were isolated and purified from ethanol extract of Callicarpa kwangtungensis by several chromatographys.Based on spectral analysis and the comparion of literatures,these compounds were identified as 3-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-2-[4-(3-hydroxy-1-(E)-propenyl)-2,6-dimethoxyphenoxy]-propyl-β-D-glucopyranoside(1),peiioside A(2),syringalide A 3′-α-L-rhanmnopyranoside(3),parvifloroside A(4),leucosceptoside B(5),alyssonoside(6),longissimoside B(7),acteoside(8),forsythoside B(9)and poliumoside(10).Compound 1 was firstly isolated from the plants of Verbenaceae,and compound 4 was firstly isolated from the plants of Callicarpa genus,while compounds 2,5 and 7 were obtained from this plant for the first time.The bacteriostatic activity results showed that four phenylpropanoids(compound 6,8,9 and 10)widespread in C.kwangtungensis had inhibitory activity against S aureus,E.coli and P.aeruginosa to some extent.This study provided the experimental basis for the clinical application of C.kwangtungensis in antibacterial fields.

关 键 词：马鞭草科 广东紫珠 苯丙素类化合物 抑菌 

分 类 号：R284[医药卫生—中药学]