CD105标记的微血管密度在口腔黏膜良性淋巴组织增生病的表达及与临床病理特征的相关性  

The expression of CD105-labeled microvessel density in benign lymphoid tissue hyperplasia of oral mucosa and its correlation with clinicopathological features

作　　者：张昊[1] 李荷香[2] 赵亚男[3] 刘慧娟 刘旭倩 侯亚丽[2] ZHANG Hao;LI Hexiang;ZHAO Ya’nan;LIU Huijuan;LIU Xuqian;HOU Yali(Hebei Key Laboratory of Stomatology,Department of Oral and Maxillofacial Surgery,Shijiazhuang 050017;Department of Oral Pathology,School and Hospital of Stomatology,Hebei Medical University,China;Hebei Medical University,Shijiazhuang;Department of Periodontics and Oral Mucosa,Affiliated Stomatology Hospital,Southwest Medical University,Luzhou)

机构地区：[1]河北省口腔医学重点实验室,河北医科大学口腔医学院·口腔医院口腔颌面外科,石家庄050017 [2]河北省口腔医学重点实验室,河北医科大学口腔医学院·口腔医院病理科,石家庄050017 [3]河北医科大学 [4]西南医科大学附属口腔医院牙周黏膜科

出　　处：《实用口腔医学杂志》2019年第6期846-850,共5页Journal of Practical Stomatology

基　　金：河北省医学科学研究重点课题(编号:ZD20140328);河北医科大学大学生创新性实验计划项目(编号:USIP2019186)

摘　　要：目的:观察微血管密度(MVD)在口腔黏膜良性淋巴组织增生病(BLOM)的表达,分析其与临床病理特征之间的相关性。方法:用免疫组织化学染色法检测CD105-MVD在30例BLOM和15例正常黏膜中的表达,分析其与临床病理特征之间的相关性。结果:与正常对照组相比,BLOM组CD105-MVD计数明显增多(P<0.05)。BLOM组内肿物型、非糜烂型和糜烂型CD105-MVD计数依次升高(P<0.05),但两两比较,CD105-MVD计数仅在肿物型和糜烂型BLOM中有统计学意义(P<0.001 7)。CD105-MVD计数和BLOM炎症程度相关,轻中度炎症组BLOM CD105-MVD计数明显低于重度炎症组(P<0.05)。结论:BLOM中有明显的血管生成现象,CD105可能参与了其中的血管形成。Objective: To observe the expression of microvessel density(MVD) in benign lymphoid tissue hyperplasia(BLOM) of oral mucosa and to analyze its correlation with clinicopathological features. Methods: Immunohistochemical staining(IHC) was used to detect the expression of CD105-MVD in 30 cases of BLOM and 15 cases of normal mucosa, the correlation between CD105-MVD and clinicopathological features was analyzed. Results: The CD105-MVD count of tumour type, non-erosive type and erosive type in BLOM group increased in turn. CD105-MVD count was higher in BLOM group than that in normal control group(P<0.05). CD105-MVD count was higher in erosive BLOM than in tumorous(P<0.001). BLOM CD105-MVD count in mild and moderate inflammation group was significantly lower than that in severe inflammation group(P<0.05). Conclusion: Vasculogenesis is evident in BLOM. CD105 may be involved in angiogenesis.

关 键 词：黏膜良性淋巴组织增生病(BLOM) CD105 MVD 病理特征 

分 类 号：R781.5[医药卫生—口腔医学]