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作 者:张昊[1] 李荷香[2] 赵亚男[3] 刘慧娟 刘旭倩 侯亚丽[2] ZHANG Hao;LI Hexiang;ZHAO Ya’nan;LIU Huijuan;LIU Xuqian;HOU Yali(Hebei Key Laboratory of Stomatology,Department of Oral and Maxillofacial Surgery,Shijiazhuang 050017;Department of Oral Pathology,School and Hospital of Stomatology,Hebei Medical University,China;Hebei Medical University,Shijiazhuang;Department of Periodontics and Oral Mucosa,Affiliated Stomatology Hospital,Southwest Medical University,Luzhou)
机构地区:[1]河北省口腔医学重点实验室,河北医科大学口腔医学院·口腔医院口腔颌面外科,石家庄050017 [2]河北省口腔医学重点实验室,河北医科大学口腔医学院·口腔医院病理科,石家庄050017 [3]河北医科大学 [4]西南医科大学附属口腔医院牙周黏膜科
出 处:《实用口腔医学杂志》2019年第6期846-850,共5页Journal of Practical Stomatology
基 金:河北省医学科学研究重点课题(编号:ZD20140328);河北医科大学大学生创新性实验计划项目(编号:USIP2019186)
摘 要:目的:观察微血管密度(MVD)在口腔黏膜良性淋巴组织增生病(BLOM)的表达,分析其与临床病理特征之间的相关性。方法:用免疫组织化学染色法检测CD105-MVD在30例BLOM和15例正常黏膜中的表达,分析其与临床病理特征之间的相关性。结果:与正常对照组相比,BLOM组CD105-MVD计数明显增多(P<0.05)。BLOM组内肿物型、非糜烂型和糜烂型CD105-MVD计数依次升高(P<0.05),但两两比较,CD105-MVD计数仅在肿物型和糜烂型BLOM中有统计学意义(P<0.001 7)。CD105-MVD计数和BLOM炎症程度相关,轻中度炎症组BLOM CD105-MVD计数明显低于重度炎症组(P<0.05)。结论:BLOM中有明显的血管生成现象,CD105可能参与了其中的血管形成。Objective: To observe the expression of microvessel density(MVD) in benign lymphoid tissue hyperplasia(BLOM) of oral mucosa and to analyze its correlation with clinicopathological features. Methods: Immunohistochemical staining(IHC) was used to detect the expression of CD105-MVD in 30 cases of BLOM and 15 cases of normal mucosa, the correlation between CD105-MVD and clinicopathological features was analyzed. Results: The CD105-MVD count of tumour type, non-erosive type and erosive type in BLOM group increased in turn. CD105-MVD count was higher in BLOM group than that in normal control group(P<0.05). CD105-MVD count was higher in erosive BLOM than in tumorous(P<0.001). BLOM CD105-MVD count in mild and moderate inflammation group was significantly lower than that in severe inflammation group(P<0.05). Conclusion: Vasculogenesis is evident in BLOM. CD105 may be involved in angiogenesis.
关 键 词:黏膜良性淋巴组织增生病(BLOM) CD105 MVD 病理特征
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