血清CHI3L1、CGRP、IL-23在慢性牙周炎患者中的表达及在病情、疗效评价中的作用探讨  

The expression of serum CHI3L1,CGRP and IL-23 in patients with chronic periodontitis and its role in the evaluation of disease severity and treatment efficacy

作　　者：高芸[1] 孙斌[1] GAO Yun;SUN Bin(First Affiliated Hospital of Medical College of Shihezi University,832008,China)

机构地区：[1]石河子大学医学院第一附属医院

出　　处：《实用口腔医学杂志》2019年第6期851-855,共5页Journal of Practical Stomatology

摘　　要：目的:探讨血清几丁质酶3样蛋白1(CHI3L1)、降钙素基因相关肽(CGRP)、白细胞介素-23(IL-23)在慢性牙周炎(CP)患者血清中的表达及在病情、疗效评价中的作用。方法:纳入106例CP患者为病例组,106例健康体检者为健康对照组。ELISA检测对比2组血清CHI3L1、CGRP、IL-23水平、病例组不同病情程度、不同疗效患者血清CHI3L1、CGRP、IL-23水平,用Spearman相关分析血清CHI3L1、CGRP、IL-23水平与CP患者病情、疗效的相关性。结果:病例组血清CHI3L1、IL-23水平高于健康对照组(P<0.05),CGRP水平低于健康对照组(P<0.05);病例组病情程度为中重度患者血清CHI3L1、IL-23水平高于轻度患者(P<0.05),血清CGRP水平低于轻度患者(P<0.05);病例组疗效较差患者血清CHI3L1、IL-23水平高于疗效良好患者(P<0.05),CGRP水平低于疗效良好患者(P<0.05);血清CHI3L1、IL-23水平与患者病情程度呈正相关(P<0.05),与疗效呈负相关(P<0.05);血清CGRP水平与CP患者病情程度呈负相关(P<0.05),与患者疗效呈正相关(P<0.05)。结论:血清CHI3L1、IL-23在CP患者中呈高表达,血清CGRP呈低表达,且其表达与患者病情、疗效密切相关。Objective: To investigate the expression of serum chitinase-like protein 1(CHI3L1),calcitonin gene-related peptide(CGRP) and interleukin-23(IL-23) in patients with chronic periodontitis(CP) and its role in the evaluation of disease severity and treatment efficacy. Methods: 106 patients with CP were included as the case group, 106 healthy subjects as the healthy controls. Serum level of CHI3L1,CGRP,and IL-23 was examined by ELISA and compared between the 2 groups. The level of the indicators with disease severity and treatment efficacy of the patients was analyzed by Spearman correlation analysis. Results: The serum level of CHI3L1 and IL-23 in the case group was higher, and CGRP level was lower than those in the control group(P<0.05). CHI3L1 and IL-23 levels in the moderate and severe CP cases were higher and CGRP level was lower than those in the mild CP cases(P<0.05). The patients with poorer treatment efficacy in the case group had higher serum CHI3L1 and IL-23 levels than in those with better efficacy and lower serum CGRP levels(P<0.05);serum CHI3L1,IL-23 levels were positively correlated with the severity of CP and negatively correlated with the treatment efficacy(P<0.05), CGRP level was negatively correlated with the severity of CP(P<0.05). Conclusion: Serum CHI3L1 and IL-23 are highly expressed and CGRP is lowly expressed in patients with CP, and their expression is closely related to the severity and treatment effect of CP.

关 键 词：慢性牙周炎(CP) CHI3L1 CGRP IL-23 病情严重程度 

分 类 号：R781.4[医药卫生—口腔医学]