莪术醇对大鼠空肠和回肠平滑肌收缩的影响  

Effects of curcumol on contraction of jejunum and ileum smooth muscles in rats

作　　者：金龙[1] 马艳庆[1] 马建秀[1] 杨宇琴 玉叶英 郭忠[1] JIN Long;MA Yan-qing;MA Jian-xiu;YANG Yu-qin;YU Ye-ying;GUO Zhong(Medical College of Northwest Minzu University,Lanzhou 730030,China)

机构地区：[1]西北民族大学医学院

出　　处：《中国药理学通报》2019年第12期1710-1713,共4页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No 81560508);中央高校基本科研业务经费项目(No 31920190058,31920180035)

摘　　要：目的探讨莪术醇对大鼠离体空肠和回肠平滑肌收缩活动的影响及机制。方法将空肠和回肠标本各随机分成5组(n=12):莪术醇组、阿托品加莪术醇组、异丙肾上腺素加莪术醇组、去甲肾上腺素加莪术醇组、Ca^2+与莪术醇组。采用恒温灌流的方法记录各组空肠、回肠的收缩振幅和张力。结果莪术醇能促进正常肠道平滑肌的收缩,并且能够对抗阿托品、去甲肾上腺素、异丙肾上腺素、维拉帕米松弛肠道平滑肌的作用。结论莪术醇能明显促进离体空肠和回肠平滑肌的收缩,这种作用可能通过M受体、α受体、β受体以及促进外钙内流等途径实现。Aim To investigate the effects of curcumol on the contractile activity of isolated jejunum and ileum smooth muscles in rats and explore its underlying mechanism.Methods Jejunum and ileum specimens were randomly divided into five groups(n=12):curcumol group,atropine plus curcumol group,isoprenaline plus curcumol group,norepinephrine plus curcumol group,Ca^2+and curcumol group.The contractile amplitude and tension of jejunum and ileum were recorded by constant temperature perfusion.Results Curcumol promoted the contraction of normal intestinal smooth muscles and antagonize the effects of atropine,norepinephrine,isoprenaline and verapamil on relaxation of intestinal smooth muscles.Conclusions Curcumol can significantly promote the contraction of isolated jejunum and ileum smooth muscles,which may be achieved through M receptor,αreceptor,βreceptor and promoting extracellular calcium influx.

关 键 词：莪术醇 平滑肌 M受体 Β受体 Α受体 CA^2+ 

分 类 号：R-332[医药卫生] R284.1