Diorganotin Complexes of N-[4-(Diethylamino)salicylidene]-(L)-tryptophane: Syntheses, Structures and Properties  

作　　者：TIAN Lai-Jin CHEN Le-Xing AN Wu-Gai LIU Xi-Cheng 田来进;陈乐兴;安五改;刘西成(Department of Chemistry,Qufu Normal University,Qufu 273165,China;Institute of Anticancer Agents Development,Qufu Normal University,Qufu 273165,China)

机构地区：[1]Department of Chemistry,Qufu Normal University,Qufu 273165,China [2]Institute of Anticancer Agents Development,Qufu Normal University,Qufu 273165,China

出　　处：《Chinese Journal of Structural Chemistry》2019年第11期1977-1985,共9页结构化学（英文）

基　　金：Financially supported by the Natural Science Foundation of Shandong Province(ZR2013BM007);the National Natural Science Foundation of China(21702119)

摘　　要：Four chiral diorganotin complexes of N-[4-(diethylamino)salicylidene]-(L)-tryptophane,R2Sn[4-(Et2N)-2-OC6H3CH=NCH(CH2Ind)COO](Ind=3-indolyl;R=Me(1);Et,(2);n-Bu(3);Cy(cyclohexyl)(4)),have been synthesized and characterized by elemental analysis,IR,and 1H and 13C NMR spectra.The crystal structures of 1-CH3OH-CHCl3,2,3-CH3OH and 4-CH3CH2OH have been determined by single-crystal X-ray diffraction.The complexes crystallize in orthorhombic system with P212121 space group,and the tin atoms are in distorted trigonal bipyramidal geometry and form five-and six-membered chelate rings with the chiral ONO tridentate ligand N-[4-(diethylamino)salicylidene]-(L)-tryptophane.In the complexes,the molecules are connected into one-dimensional supramolecular chain by intermolecular N–H…O–H…O=C or N–H…O–C hydrogen bonds.The fluorescence spectrum indicates that the complexes may be explored for potential blue luminescent materials.Bioassay results show that 3 and 4 belong to the efficient cytostatic agents against A549 human tumor cell.

关 键 词：ORGANOTIN complex SCHIFF base CRYSTAL structure ANTITUMOR activity FLUORESCENCE 

分 类 号：O62[理学—有机化学]