2403例肺癌临床流行病学分析  

Clinical epidemiological analysis of 2403 cases of lung cancer

作　　者：汪育锦 黄静宇[1] 胡卫东[1] 李胜[2] 唐政 杨泽天[1] 沈小艳 宋从宽 李飞[3] Wang Yujin;Huang Jingyu;Hu Weidong;Li Sheng;Tang Zheng;Yang Zetian;Shen Xiaoyan;Song Congkuan;Li Fei(Department of Cardiovascular Thoracic Surgery,Zhongnan Hospital of Wuhan University,Hubei Cancer Clinical Study Center,Hubei Key Laboratory of Tumor Biological Behaviors,Wuhan 430071,China;Department of Biological Repositories,Zhongnan Hospital of Wuhan University,Human Genetics Resource Preservation Center of Hubei Province,Wuhan 430071,China;Department of Medical Record,Zhongnan Hospital of Wuhan University,Wuhan 430071,China)

机构地区：[1]武汉大学中南医院胸心血管外科,湖北省肿瘤临床研究中心,肿瘤生物学行为湖北省重点实验室,430071 [2]武汉大学中南医院生物样本库湖北省人类遗传资源保藏中心,430071 [3]武汉大学中南医院病案室,430071

出　　处：《国际肿瘤学杂志》2019年第8期460-465,共6页Journal of International Oncology

基　　金：湖北省卫生和计划生育委员会重点支撑项目(WJ2017Z006);武汉大学中南医院科技创新培育基金(cxpy2017041)。

摘　　要：目的回顾性分析2013—2017年武汉大学中南医院2403例肺癌病例,以初步了解近年来肺癌的流行病学变化趋势。方法收集2013—2017年5年间武汉大学中南医院诊断为原发性支气管肺癌的住院患者病历资料,对患者的性别、年龄、烟酒史、手术情况、病理类型、临床分期及表皮生长因子受体(EGFR)基因突变情况等临床资料进行统计学分析。结果共收集肺癌病例2403例,其中男性1766例,女性637例。5年间,肺癌患者男女比例差异无统计学意义(χ2=8.481,P=0.075)。有年龄信息的病例共2398例,<40岁、40~49岁、50~59岁、60~69岁、70~79岁、≥80岁年龄段的肺癌患者男女比例分别为0.9∶1.0、1.4∶1.0、2.4∶1.0、3.6∶1.0、3.4∶1.0、3.3∶1.0,差异具有统计学意义(χ2=59.004,P<0.001)。5年间腺癌构成比差异无统计学意义(χ2=2.165,P=0.705);鳞状细胞癌构成比差异无统计学意义(χ2=4.788,P=0.310)。5年间腺癌在男、女性患者的各类病理类型中分别占43.15%(762/1766)和81.95%(522/637),差异有统计学意义(P<0.001);鳞状细胞癌分别占39.01(689/1766)%和7.38%(47/637),差异有统计学意义(P<0.001)。吸烟患者中鳞状细胞癌占比为42.99%(583/1356),明显高于非吸烟患者的14.61%(153/1047);饮酒患者中鳞状细胞癌占比为40.56%(277/683),高于非饮酒患者的26.69%(459/1720),差异均有统计学意义(均P<0.001)。手术患者共1252例,占所统计病例的52.10%(1252/2403);小细胞癌的手术率为21.72%(48/221),非小细胞癌的手术率为55.18%(1204/2182);5年间,患者的手术比例分别为55.11%(221/401)、51.53%(252/489)、58.23%(244/419)、53.18%(276/519)、45.04%(259/575),各年份手术与非手术患者构成比的差异有统计学意义(χ2=19.553,P=0.001)。检测EGFR是否突变的肺癌患者共483例,腺癌患者中EGFR突变率为58.8%(251/427),鳞状细胞癌患者中EGFR突变率为15.6%(5/32)。<40岁、40~49岁、50~59岁、60~69岁、70~79岁、≥80岁年龄段的肺癌患者Objective To understand preliminaryly the epidemiological trend of lung cancer in recent years by retrospective analysis of 2403 cases of lung cancer in Zhongnan Hospital of Wuhan University from 2013 to 2017.Methods The clinical data of patients with primary bronchogenic cancer diagnosed in Zhongnan Hospital of Wuhan University from 2013 to 2017 were collected.The clinical data such as gender,age,history of tobacco and alcohol,operation,pathological type,clinical stage and epidermal growth factor receptor(EGFR)gene mutation were analyzed statistically.Results A total of 2403 cases of lung cancer were collected,including 1766 males and 637 females.There was no significant difference in gender ratio between male and female in five years(χ2=8.481,P=0.075).There were 2398 cases with age information,the male-to-female ratios of lung cancer patients aged less than 40,40-49,50-59,60-69,70-79,80 and over were 0.9∶1.0,1.4∶1.0,2.4∶1.0,3.6∶1.0,3.4∶1.0 and 3.3∶1.0 respectively,and the difference was statistically significant(χ2=59.004,P<0.001).The composition difference of adenocarcinoma was not statistically significant in five years(χ2=2.165,P=0.705).There was no statistically significant difference in the composition ratio of squamous cell carcinoma(χ2=4.788,P=0.310).Adenocarcinoma accounted for 43.15%(762/1766)and 81.95%(522/637)of the pathological types of male and female patients respectively,and the difference was statistically significant(P<0.001).Squamous cell carcinoma accounted for 39.01%(689/1766)and 7.28%(47/637)respectively,and the difference was statistically significant(P<0.001).The proportion of squamous cell carcinoma in smoking patients was 42.99%(583/1356),which was significantly higher than that in non-smoking patients(14.61%,153/1047);the proportion of squamous cell carcinoma in drinking patients was 40.56%(277/683),which was higher than that in non-drinking patients(26.69%,459/1720),and the differences were statistically significant(both P<0.001).A total of 1252 patients underwent surg

关 键 词：肺肿瘤 流行病学 病理学 

分 类 号：R73[医药卫生—肿瘤]