脑血运重建手术治疗非痴呆型血管性认知功能障碍临床研究  

Clinical study of cerebral revascularization surgery for non-dementia vascular cognitive dysfunction

作　　者：马继伟[1] 赵新利[1] 黄立勇[1] 周文科[1] 张新中[1] Ma Jiwei;Zhao Xinli;Huang Liyong;Zhou Wenke;Zhang Xinzhong(The First Affiliated Hospital of Xinxiang Medical College,Weihui 453100,Henan,China)

机构地区：[1]新乡医学院第一附属医院,河南卫辉453100

出　　处：《临床心身疾病杂志》2019年第6期11-14,共4页Journal of Clinical Psychosomatic Diseases

基　　金：国家自然科学基金项目(编号81541030)。

摘　　要：目的探讨脑血运重建手术治疗非痴呆型血管性认知功能障碍的临床疗效.方法对17例非痴呆型血管性认功能障碍患者应用颅内外联合脑血运重建技术治疗,术后6个月复查.对术前与术后6个月患者的脑动脉血管造影、脑CT灌注图像进行分析,并比较手术前后脑血流动力学参数及简易精神状态检查量表、改良Rankin量表评分.结果本组17例患者均手术成功,无手术死亡病例;术后6个月血管吻合口通畅率为70.59%(12/17),脑皮层血管侧支形成增多;脑组织灌注参数及简易精神状态检查量表、改良Rankin量表评分均较术前明显改善(P<0.05或0.01).结论脑血运重建手术治疗非痴呆型血管性认知功能障碍安全有效,能够增加脑组织灌注,明显改善患者认知功能,提高其生活质量.Objective To explore the clinical efficacy of cerebral revascularization surgery for non-dementia vascular cognitive dysfunction.Methods 17 patients with non-dementia vascular cognitive impairment were treated with extracranial and intracranial combined cerebral revascularization,and were reviewed 6 months after surgery.The DSA and CTP of patients before and 6 months after operation were analyzed,and the cerebral hemodynamic parameters and MMSE and mRS scores were compared before and after operation.Results 17 cases were successfully operated without death.The patency rate of vascular anastomosis was 70.59%(12/17),and collateral vessel formation was increased.Cerebral hemodynamic parameters,MMSE and mRS scores were significantly improved(P<0.05 or 0.01).Conclusions Combined cerebral revascularization is safe and effective,which can increase cerebral perfusion,improve cognitive function and improve quality of life.

关 键 词：非痴呆型血管性认知障碍 颞浅动脉 脑血运重建 简易精神状态检查量表 

分 类 号：R743[医药卫生—神经病学与精神病学] R651.11[医药卫生—临床医学]