美金刚联合小剂量喹硫平治疗阿尔茨海默病伴精神行为症状患者疗效分析  

Efficacy analysis of memantine combined with low-dose quetiapine in the treatment of Alzheimers disease with mental behavioral symptoms

作　　者：宋燕[1] 吴贻明 Song Yan;Wu Yiming(Yangpu District Mental Health Center of Shanghai,Shanghai 200090,China)

机构地区：[1]上海市杨浦区精神卫生中心,上海200090

出　　处：《临床心身疾病杂志》2019年第6期146-148,共3页Journal of Clinical Psychosomatic Diseases

摘　　要：目的探讨美金刚联合小剂量喹硫平治疗阿尔茨海默病伴精神行为症状的临床疗效及对患者认知功能的影响.方法将116例阿尔茨海默病伴精神行为症状患者按随机数字表法分为两组,观察组57例,对照组59例.两组均予以美金刚治疗,观察组在此基础上联合喹硫平治疗,观察12周.于治疗前后,采用阿尔茨海默病行为病理评定量表、简易智力状态检查量表评定精神行为症状及认知功能,副反应量表评定不良反应.结果治疗8周末起,两组阿尔茨海默病行为病理评定量表评分较治疗前显著降低(P<0.05),观察组显著低于对照组(P<0.05);两组简易智力状态检查量表评分较治疗前显著升高(P<0.05),组间比较差异无统计学意义(P>0.05).两组不良反应发生率比较差异无统计学意义(P>0.05).结论美金刚联合小剂量喹硫平治疗阿尔兹海默病伴精神行为症状疗效显著,优于单用美金刚治疗,但二者对认知功能改善效果相当.Objective To investigate the clinical efficacy of memantine combined with low-dose quetiapine in the treatment of Alzheimers disease with mental behavioral symptoms and its impact on cognitive function.Methods 116 patients with Alzheimers disease and mental behavior were divided into two groups according to the random number table,57 cases in the observation group and 59 cases in the control group.The two groups were treated with memantine,and the observation group was treated with quetiapine on the basis of this for 12 weeks.Before and after treatment,BEHAVE-AD and MMSE were used to assess mental behavioral symptoms and cognitive function,and TESS was used to evaluate adverse reactions.Results After 8 weeks of treatment,the BEHAVE-AD scores of the two groups were significantly lower than those before treatment(P<0.05),and the observation group was significantly lower than the control group(P<0.05).The MMSE scores of the two groups were significantly higher than those before treatment(P<0.05).There was no significant difference between the two groups(P>0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P〉0.05).Conclusions Memantine combined with low-dose quetiapine tablets is effective in the treatment of Alzheimers disease with mental behavioral symptoms,which is superior to memantine alone,but the effect on cognitive function improvement is comparable.

关 键 词：阿尔茨海默病 精神行为症状 美金刚 喹硫平 

分 类 号：R749.16[医药卫生—神经病学与精神病学] R749.053[医药卫生—临床医学]