细胞信号转导通路与肝癌相关性研究进展  

Progress in research on association between cell signal transduction pathways and hepatocellular carcinoma

作　　者：陈椿 杨哲 黄赞松[2] Chun Chen;Zhe Yang;Zan-Song Huang(Graduate School of Youjiang Medical College for Nationalities,Baise 533000,Guangxi Zhuang Autonomous Region,China;Department of Gastroenterology,Affiliated Hospital of Youjiang Medical College for Nationalities,Guangxi Clinical Research Center for Hepatobiliary Diseases,Baise 533000,Guangxi Zhuang Autonomous Region,China)

机构地区：[1]右江民族医学院研究生学院,广西壮族自治区百色市533000 [2]右江民族医学院附属医院消化内科,广西肝胆疾病临床医学研究中心,广西壮族自治区百色市533000

出　　处：《世界华人消化杂志》2019年第21期1330-1338,共9页World Chinese Journal of Digestology

基　　金：广西自然科学基金资助项目,No.2014GXNSFAA118143;广西科技基地与人才专项(广西肝胆疾病临床医学研究中心研究课题),No.AD17129025;2017年度广西医药卫生自筹经费计划课题,No.Z20170224~~

摘　　要：细胞信号转导是指信号分子通过刺激胞膜或者胞内受体,引起细胞内发生信号转导,从而影响细胞生物学功能的过程.近年来研究发现,某些细胞信号转导通路的激活或者抑制在肝癌(hepatocellular carcinoma,HCC)细胞的发生、发展中起着重要推动作用.本文将对近年来有关HCC的热门细胞信号转导通路的研究进行综述.Cell signal transduction refers to the process by which a signal molecule induces signal transduction in a cell by stimulating the cell membrane or intracellular receptor,thereby affecting the biological function of the cell.In recent years,studies have found that the activation or inhibition of certain cell signal transduction pathways plays an important role in the development and progression of hepatocellular carcinoma.This article will review the recent research progress in the understanding of the role of some common signal transduction pathways in hepatocellular carcinoma.

关 键 词：信号转导 肝癌 发生机制 

分 类 号：R73[医药卫生—肿瘤]