铁死亡逆转肿瘤细胞化疗药物耐药性的研究进展  

Role of ferroptosis in reversing drug resistance of tumor cells

作　　者：周程成 陈秀生 周智辉 ZHOU Chengcheng;CHEN Xiusheng;ZHOU Zhihui(Grade 2017,Shaanxi University of Chinese Medicine,Xianyang 712046,China;Department of Haematology,West Power Group Hospital,Xi’an 710077,China;Department of Scientific Research,the Second Affiliated Hospital of Shaanxi University of Chinese Medicine,Xianyang 712000,China)

机构地区：[1]陕西中医药大学,陕西咸阳712046 [2]西电集团医院血液病科,西安710077 [3]陕西中医药大学第二附属医院科研科,陕西咸阳712000

出　　处：《中华实用诊断与治疗杂志》2019年第11期1128-1130,共3页Journal of Chinese Practical Diagnosis and Therapy

基　　金：陕西省教育厅科学研究计划项目(18JK0218);陕西省卫生健康科研基金(2018D087);陕西中医药大学学科创新团队项目(2019-YS03)

摘　　要：恶性肿瘤是人类死亡的主要原因之一,临床治疗常采用手术辅以放、化疗的综合措施。化疗药物耐药是肿瘤细胞转移和侵袭的主要因素,影响患者预后。铁死亡是一种新型细胞程序性死亡方式,诱导铁死亡可逆转肿瘤细胞对化疗药物的耐药性。本文就铁死亡逆转肿瘤细胞化疗药物耐药性的研究进展作一综述。Malignant tumor is one of the main causes of human death.Comprehensive treatment with radiotherapy and chemotherapy is often used after surgery.Chemotherapeutic drug resistance is an important influencing factor for the metastasis and invasion of tumor cells,and is closely correlated with the prognosis of patients.Ferroptosis is a novel mode of programmed cell death,which can reverse the tumor cell resistance to chemotherapy by inducing ferroptosis.This paper reviews the research progress of reversing tumor chemoresistance by inducing ferroptosis.

关 键 词：恶性肿瘤 铁死亡 化疗药物耐药 

分 类 号：R73[医药卫生—肿瘤]