Rh-incompatible hemolytic disease of the newborn in Hefei  

作　　者：Shao-Hua Bi Liang-Liang Jiang Li-Ying Dai Hong Zheng Jian Zhang Li-Li Wang Chao Wang Qiao Jiang Yu Liu Yong-Li Zhang Juan Wang Chao Zhu Guang-Hui Liu Ru-Jeng Teng 

机构地区：[1]Divisions of Neonatology,Anhui Provincial Children’s Hospital,Hefei 230022,Anhui Province,China [2]Pediatrics Neurology,Anhui Provincial Children’s Hospital,Hefei 230022,Anhui Province,China [3]Division of Neonatology,First Affiliated Hospital of Anhui Medical University,Hefei 230022,Anhui Province,China [4]Hefei Blood Center,Hefei 230022,Anhui Province,China [5]Clinical pathology,Anhui Provincial Children’s Hospital,Hefei 230022,Anhui Province,China [6]Division of Neonatology,Department of Pediatrics,Medical College of Wisconsin,Milwaukee,WI 53226,United States

出　　处：《World Journal of Clinical Cases》2019年第20期3202-3207,共6页世界临床病例杂志

摘　　要：BACKGROUND Anti-D antibody is not the common cause of Rh-isoimmunization in Chinese neonatal jaundice.Recent change in national population policy has followed by an increase in Rh-isoimmunization related hemolytic disease of the newborn(HDN).Unfortunately,regional status of Rh-HDN is unavailable.We hypothesize that Rh-HDN in our region is most commonly due to anti-E antibody.AIM To investigate the prevalence of hemolytic disease of the newborn due to Rhisoimmunization in Hefei City.METHODS Retrospective review of data obtained from Children’s Hospital of Anhui and Hefei Blood Center between January 2017 and June 2019.Status of minor blood group antibody was studied in the corresponding mothers.RESULTS Totally 4138 newborns with HDN admitted during the study period and 116(2.8%)received blood exchange transfusion(BET).Eighteen newborns(0.43%)with proven Rh-incompatible HDN were identified.All were not the first-born baby.Thirteen mothers were RhD(+)(72%)and five were RhD(-).The distribution of Rh-related antibodies in mothers was ten anti-E(55%),five anti-D(27%),and for one anti-C,anti-c,and anti-E/c(6%)each.Thirteen(72.2%)were qualified for BET,relative risk for BET was 28.9 as compared to other types of HDN,but only 10 received due to parenteral refusal.All(100%)RhD related HDN received BET which is not significantly different from RhE related HDN(81.8%).CONCLUSION As expected,all Rh-incompatible HDN newborns were not the first-born.Contrary to the Caucasian population,anti-D induced HDN is not the most common etiology.In our region,anti-E(11/18,61%)is the most common cause of Rh-HDN.BACKGROUND Anti-D antibody is not the common cause of Rh-isoimmunization in Chinese neonatal jaundice. Recent change in national population policy has followed by an increase in Rh-isoimmunization related hemolytic disease of the newborn(HDN). Unfortunately, regional status of Rh-HDN is unavailable. We hypothesize that Rh-HDN in our region is most commonly due to anti-E antibody.AIM To investigate the prevalence of hemolytic disease of the newborn due to Rhisoimmunization in Hefei City.METHODS Retrospective review of data obtained from Children’s Hospital of Anhui and Hefei Blood Center between January 2017 and June 2019. Status of minor blood group antibody was studied in the corresponding mothers.RESULTS Totally 4138 newborns with HDN admitted during the study period and 116(2.8%) received blood exchange transfusion(BET). Eighteen newborns(0.43%)with proven Rh-incompatible HDN were identified. All were not the first-born baby. Thirteen mothers were RhD(+)(72%) and five were RhD(-). The distribution of Rh-related antibodies in mothers was ten anti-E(55%), five anti-D(27%), and for one anti-C, anti-c, and anti-E/c(6%) each. Thirteen(72.2%) were qualified for BET, relative risk for BET was 28.9 as compared to other types of HDN, but only 10 received due to parenteral refusal. All(100%) RhD related HDN received BET which is not significantly different from RhE related HDN(81.8%).CONCLUSION As expected, all Rh-incompatible HDN newborns were not the first-born.Contrary to the Caucasian population, anti-D induced HDN is not the most common etiology. In our region, anti-E(11/18, 61%) is the most common cause of Rh-HDN.

关 键 词：Rh-isoimmunization HEMOLYTIC disease of the NEWBORN MINOR BLOOD group 

分 类 号：R72[医药卫生—儿科]