动态血清S100B蛋白浓度监测及血糖变异性对脑出血患者近期预后评估意义  

Significance of Dynamic Serum S100B Protein Concentration Monitoring and Blood Glucose Variability in Evaluating the Short-term Prognosis of Patients with Cerebral Hemorrhage

作　　者：石波 崔惠芬 李远辉 骆伟光 杨泽敏 SHI Bo;CUI Huifen;LI Yuanhui;LUO Weiguang;YANG Zemin(Liaobu Hospital of Guangdong Medical University,Dongguan 523400,China)

机构地区：[1]广东医科大学寮步医院

出　　处：《中外医学研究》2019年第31期70-72,共3页CHINESE AND FOREIGN MEDICAL RESEARCH

基　　金：东莞市科技局社会科技发展项目(项目编号：2018507150391497)

摘　　要：目的:探究动态血清S100B蛋白浓度监测及血糖变异性对脑出血患者近期预后的评估意义。方法:选取笔者所在医院收治的70例急性脑出血患者为试验组,采用免疫荧光层析法对S100B蛋白浓度进行检测。另选取同期健康体检者45例为参照组。对比试验组手术患者与参照组血清S100B蛋白浓度,分析S100B蛋白浓度与血肿量、NIHSS评分的相关性。试验组中有55例存活,15例死亡,观察并记录存活与死亡患者血糖平均值、初始血糖、血糖变异系数及标准差,探究死亡与血糖变异性的关系。结果:试验组手术患者术前血清S100B蛋白浓度显著高于参照组,差异有统计学意义(P<0.05);试验组手术患者术后血清S100B蛋白浓度与参照组比较,差异无统计学意义(P>0.05);试验组大量出血、中量出血患者血清S100B蛋白浓度均明显高于少量出血患者,差异均有统计学意义(P<0.05);血清S100B蛋白浓度与NIHSS评分、血肿量呈正相关(P<0.05)。15例死亡患者的血糖变异系数、血糖标准差均显著高于55例存活患者,差异均有统计学意义(P<0.05)。结论:在急性脑出血患者中S100B蛋白高表达可作为临床判断急性脑出血治疗效果及出血严重程度标志物,血糖变异性与脑出血预后有密切联系,两项指标均可为临床诊断、评估脑出血预后提供有效依据。Objective: To investigate the significance of dynamic serum S100 B protein concentration monitoring and blood glucose variability in evaluating the short-term prognosis of patients with cerebral hemorrhage. Method: A total of 70 patients with acute cerebral hemorrhage in our hospital were selected as the experimental group, and the concentration of S100 B protein was detected by immunofluorescence chromatography. And 45 healthy subjects were selected as the reference group. The serum S100 B protein concentrations were compared between the experimental group of surgical patients and the reference group, and the correlation between S100 B protein concentration and hematoma volume and NIHSS score were analyzed. And 55 patients survived, 15 patients died in the experimental group. Blood glucose mean value, initial blood glucose, coefficient of variation and standard deviation of patients with survival and death were observed and recorded, and the relationship between death and blood glucose variability was explored. Result: Before surgery, serum S100 B protein concentration of the experimental group of surgical patients was significantly higher than that of the reference group, and the difference was statistically significant(P<0.05). After surgery, serum S100 B protein concentration of the experimental group of surgical patients was compared with that of the reference group, and the difference was not statistically significant(P>0.05). The serum S100 B protein concentration of patients with massive and moderate bleeding in the experimental group were significantly higher than that of patients with minor bleeding, and the differences were statistically significant(P<0.05). Serum S100 B protein concentration was positively correlated with NIHSS score and hematoma volume(P<0.05). The coefficient of variation and standard deviation of blood glucose in 15 died patients were significantly higher than those of 55 survived patients, and the differences were statistically significant(P<0.05). Conclusion: The high expression

关 键 词：脑出血 血糖变异性 S100B蛋白 脑损伤 血肿量 NIHSS评分 

分 类 号：R74[医药卫生—神经病学与精神病学]