红色诺卡氏菌细胞壁骨架胸腔内注射治疗恶性胸腔积液的临床效果  

Clinical effects of intrathoracic injection of red Nocardia cell wall skeleton in the treatment of malignant pleural effusion

作　　者：齐利[1] 陈岩[2] Qi Li;Chen Yan(Department of Cardiothoracic Surgery,Longnan Hospital of Daqing,Daqing 163453,China;Department of B-Ultrasound Room,Longnan Hospital of Daqing,Daqing 163453,China)

机构地区：[1]黑龙江大庆龙南医院心胸外科,163453 [2]黑龙江大庆龙南医院B超室,163453

出　　处：《中国实用医刊》2019年第20期104-106,共3页Chinese Journal of Practical Medicine

摘　　要：目的探讨红色诺卡氏菌细胞壁骨架(N-CWS)胸腔内注射治疗恶性胸腔积液的临床效果.方法回顾性分析大庆龙南医院2016年8月至2018年10月90例恶性胸腔积液患者的临床资料,其中33例接受顺铂治疗(顺铂组),38例接受N-CWS治疗(N-CWS组),19例接受化疗联合N-CWS治疗(联合组),比较三组临床疗效和不良反应.结果顺铂组治疗总有效率为48.48%,胸水癌细胞转阴率为48.48%;N-CWS组治疗总有效率为84.21%,胸水癌细胞转阴率为78.94%;联合组治疗总有效率为89.47%,胸水癌细胞转阴率为84.21%;三组治疗总有效率和胸水癌细胞转阴率呈现出逐渐升高趋势,差异有统计学意义(P<0.05);顺铂组主要不良反应为胃肠道反应,N-CWS组主要不良反应为发热、胸疼痛和胸膜增厚.结论N-CWS可有效治疗恶性胸腔积液,且不良反应少.Objective To investigate the effects of intrathoracic injection of red Nocardia cell wall skeleton(N-CWS)in the treatment of malignant pleural effusion.Methods The clinical data of 90 patients with malignant pleural effusion in Longnan Hospital of Daqing from August 2016 to October 2018 were analyzed retrospectively,including 33 cases treated with cisplatin(cisplatin group),38 cases treated with N-CWS(N-CWS group)and 19 cases treated by chemotherapy combined with N-CWS(combined group).The clinical efficacy and adverse reactions of the three groups were compared.Results The total effective rate of cisplatin group was 48.48%,and the negative rate of pleural effusion cancer cells was 48.48%.The total effective rate of N-CWS group was 84.21%,and the negative rate of pleural effusion cancer cells was 78.94%.The total effective rate of the combined group was 89.47%,and the negative rate of the pleural effusion cancer cells was 84.21%.The total effective rate of the three groups and the negative conversion rate of pleural cancer cells showed a gradual upward trend,and the difference was significant(P<0.05).The main adverse reaction in cisplatin group was gastrointestinal reactions,the main adverse reactions in N-CWS group were fever,chest pain and pleural thickening.Conclusions N-CWS is effective in the treatment of malignant pleural effusions with few adverse reaction.

关 键 词：恶性胸腔积液 红色诺卡氏菌细胞壁骨架 胸腔内注射 临床疗效 不良反应 

分 类 号：R73[医药卫生—肿瘤]