益气升降汤辅助治疗对结肠癌患者术后功能的影响  

Effect of Yiqi Shengjiang Decoction assisted therapy on postoperative function of patients with colon cancer

作　　者：童林萍 潘一红[2] 陶德友 TONG Lin-ping;PAN Yi-hong;TAO De-you(Clinical Internal Medicine Department of Traditional Chinese and Western Medicine,the First People's Hospital of Wenling,Wenling,Zhejiang 317500,China)

机构地区：[1]温岭市第一人民医院中西医临床内科,浙江温岭317500 [2]台州市中心医院妇产科,浙江台州318000 [3]台州恩泽医院甲乳外科,浙江台州317000

出　　处：《中华全科医学》2019年第12期2096-2098,2154,共4页Chinese Journal of General Practice

基　　金：浙江省医药卫生科技计划项目(2016KY194)

摘　　要：目的探讨益气升降汤辅助治疗对结肠癌患者胃肠动力、免疫功能及生活质量的影响。方法随机数字法将2016年1月-2018年1月间在温岭市第一人民医院接受治疗的178例结肠癌术后患者分为2组,每组89例。对照组给予XELOX方案化疗,观察组在对照组的基础上加用益气升降汤,2组均治疗3个周期。治疗后,比较2组患者胃肠动力恢复情况(第一次肠鸣音时间、肛门排气时间、排便时间、住院时间)及免疫功能(CD3^+、CD4^+、CD8^+、CD4^+/CD8^+)、外周血细胞水平[红细胞(RBC)、白细胞(WBC)、血小板(PLT)及血红蛋白(HB)]、生活质量(SF-36)的变化。结果观察组第一次肠鸣音时间、肛门排气时间、排便时间及住院时间显著低于对照组(均P<0.05)。治疗后,对照组CD3^+、CD4^+、CD8^+及CD4^+/CD8^+水平无明显变化(均P>0.05),观察组CD3^+、CD4^+及CD4^+/CD8^+水平显著升高(均P<0.05),CD4^+水平明显降低(P<0.05),且均显著优于对照组(均P<0.05)。治疗后,观察组RBC、WBC、PLT及HB水平无明显下降(均P>0.05),对照组RBC、WBC、PLT及HB水平显著降低(均P<0.05),且观察组显著高于对照组(均P<0.05)。治疗后,2组生理功能、心理职能、躯体疼痛、健康状况、社会职能、精力、精神健康及情感职能评分均明显升高(均P<0.05),且观察组显著高于对照组(均P<0.05)。结论益气升降汤辅助治疗可明显促进结肠癌术后患者胃肠动力恢复,增强患者机体免疫功能,减轻患者化疗后血液学毒性反应,从而有助于提高患者的生活质量。Objective To investigate the effect of Yiqi Shengjiang Decoction on gastrointestinal motility,immune function and quality of life in patients with colon cancer.Methods A total of 178 patients with postoperative colon cancer who were treated in our hospital from January 2016 to January 2018 were randomly divided into two groups,89 cases in each group.The control group was given XELOX regimen chemotherapy,and the observation group was supplemented with Yiqi Shengjiang Decoction on the basis of the control group,both groups were treated for 3 cycles.After treatment,the changes of gastrointestinal motility recovery(first bowel sound time,anal exhaust time,defecation time,hospital stay)and immune function(CD3^+,CD4^+,CD8^+,CD4^+/CD8^+)and peripheral blood cell levels(RBC,WBC,PLT,HB),quality of life(SF-36)were compared between the two groups.Results The first bowel sound time,anal exhaust time,defecation time and hospital stay in the observation group were significantly lower than those in the control group(all P<0.05).After treatment,the levels of CD3^+,CD4^+,CD8^+and CD4^+/CD8^+in the control group did not change significantly(all P>0.05),the levels of CD3^+,CD4^+and CD4^+/CD8^+in the observation group were significantly increased(all P<0.05),and the level of CD4^+was significantly decreased(P<0.05),and all of them were significantly better than the control group(all P<0.05).After treatment,the levels of RBC,WBC,PLT and HB in the observation group did not decrease significantly(all P>0.05),and the levels of RBC,WBC,PLT and HB in the control group decreased significantly(all P<0.05),and the observation group was significantly higher than the control group(all P<0.05).After treatment,the physiological function,psychological function,physical pain,health status,social function,energy,mental health and emotional function scores of the two groups were significantly increased(all P<0.05),and the observation group was significantly higher than the control group(all P<0.05).Conclusion Yiqi Shengjiang Decoction can significan

关 键 词：结肠癌术后 益气升降汤 胃肠动力 免疫功能 生活质量 

分 类 号：R735.35[医药卫生—肿瘤] R730.7[医药卫生—临床医学]