以红斑结节反复发作为主要表现的皮肤假性淋巴瘤1例  

A Case of Cutaneous Pseudolymphoma with Recurrent Erythema and Nodules as the Main Manifestation

作　　者：赵艳霞[1] 赵磊 王雅莉 张智涵 ZHAO Yanxia;ZHAO Lei;WANG Yali;ZHANG Zhihan(Affiliated Hospital of Tianjin Institute of Traditional Chinese Medicine,Tianjin 300120,China;Tianjin University of Traditional Chinese Medicine,Tianjin 300110,China;Kunming Third People's Hospital,Kunming 650041,China)

机构地区：[1]天津市中医药研究院附属医院,天津300120 [2]天津中医药大学,天津300110 [3]昆明市第三人民医院,云南昆明650041

出　　处：《中国皮肤性病学杂志》2019年第12期1405-1408,共4页The Chinese Journal of Dermatovenereology

摘　　要：患者男,47岁,躯干上臂反复出现多个红斑结节半年。皮肤科情况:躯干部、上臂多个红斑、结节,散在孤立,最大约3 cm×2 cm,边界清,表面光滑,质地中等,无鳞屑,无破溃,无压痛。背部皮损组织病理示:表皮大致正常,真皮中上层可见血管周围弥漫性淋巴细胞浸润,部分为浆细胞,淋巴细胞以小到中等为主,并见个别大细胞。免疫组织化学示:CD3、CD4、CD20、CD79、Bcl-2均为阳性,CD10、CD30阴性,Ki-67<20%。抗原受体基因克隆性重排PCR检测(BIOMED-2)示:淋巴细胞受体多克隆性重排。病理诊断:皮肤淋巴组织增生。诊断:皮肤假性淋巴瘤。A 47-year-old male patient had recurrent multiple erythema and nodules in his trunk and upper arm for half a year.A dermatologic examination found many scattered and isolated erythema and nodules in his trunk and upper arm,the max size was about 3 cm×2 cm,characterized by clear border,smooth surface,medium texture,no scales,no ulceration and no tenderness.Histopathological examination of the skin(lesion at the back)showed normal epidermis,and diffused lymphocytic infiltration around blood vessels in the upper and middle dermis.Most of the lymphocytes were small to medium size,but some large cells also could be seen.Immunohistochemistry found CD3(+),CD4(+),CD20(+),CD79a(+),Bcl-2(+),CD30(-),CD10(-)cells,and Ki-67<20%.BIOMED-2 multiplex PCRshowed lymphocyte receptor polyclonal rearrangement.The pathological diagnosis was cutaneous lymphoid hyperplasia.The diagnosis of cutaneous pseudolymphoma was made.

关 键 词：红斑结节 皮肤 假性淋巴瘤 

分 类 号：R739.5[医药卫生—肿瘤]