急性淋巴细胞白血病患儿化疗期间生命质量及其影响因素的纵向研究  

Longitudinal study on quality of life and its influencing factors in children with acute lymphoblastic leukemia during chemotherapy

作　　者：李蓉蓉 阐玉英[2] 马金玲 杨琦[1] 郑鹏飞 Li Rongrong;Chan Yuying;Ma Jinling;Yang Qi;Zheng Pengfei(Department of Hematologists,Children′s Hospital Affiliated to Soochow University,Suzhou 215025,China;Discipline Supervision Office,Children′s Hospital Affiliated to Soochow University,Suzhou 215025,China;School of Nursing,Medical College of Soochow University,Suzhou 215006,China)

机构地区：[1]苏州大学附属儿童医院血液科,215025 [2]苏州大学附属儿童医院纪监审办公室,215025 [3]苏州大学医学部护理学院,215006

出　　处：《中国实用护理杂志》2019年第34期2676-2681,共6页Chinese Journal of Practical Nursing

摘　　要：目的探讨急性淋巴细胞白血病患儿化疗期间生命质量的动态变化及其影响因素。方法便利选取134例急性淋巴细胞白血病患儿,运用一般资料调查表、儿童生命质量普适性核心量表对患儿化疗第1、3、6个月进行问卷调查。结果急性淋巴细胞白血病患儿化疗不同时间点的生命质量水平比较差异有统计学意义(t=-23.117~209.225,P<0.01);多因素分析发现,化疗第1个月影响患儿生命质量的因素为年龄(t=-10.413,P=0.000)、家庭情感支持(t=2.231,P=0.027);化疗第3个月影响患儿生命质量的因素为年龄(t=-12.439,P=0.000)、独生子女(t=2.267,P=0.025)、主要照顾者文化程度(t=2.091,P=0.038)及家庭情感支持(t=5.374,P=0.014);化疗第6个月影响患儿生命质量的因素为年龄(t=-11.254,P=0.000)和家庭情感支持(t=2.184,P=0.035)。结论急性淋巴细胞白血病患儿的生命质量总分及各维度得分均较低并呈现动态变化,患儿年龄和家庭情感支持是生命质量的持续影响因素,医护人员应根据不同年龄阶段患儿生命质量的特点,采取针对性的干预方案,并指导和帮助父母与患儿建立良好的家庭情感支持,改善生命质量。Objective To investigate the dynamic changes of quality of life and its influencing factors in children with acute lymphoblastic leukemia during chemotherapy.Methods A total of 134 children who were diagnosed with acute lymphoblastic leukemia were selected.The demographic questionnaire and Pediatric Quality of Life InventoryTM General Core Module were completed in children at three different time points during chemotherapy(the first month,the third month,and the sixth month of chemotherapy).Results There were significant differences in the quality of life between children with acute lymphoblastic leukemia(t=-23.117-209.225,P<0.01).Multiple factors analysis showed that the factors influencing the quality of life of children at the first month of chemotherapy were age(t=-10.413,P=0.000),and family emotional support(t=2.231,P=0.027);the factors at the third month of chemotherapy included age(t=-12.439,P=0.000),whether the child was the only child(t=2.267,P=0.025),education level of primary caregiver(t=2.091,P=0.038),and family emotional support(t=5.374,P=0.014);the factor at the sixth month of chemotherapy were age(t=-11.254,P=0.000),and family emotional support(t=2.184,P=0.035).Conclusions The total quality of life and the scores of all dimensions of children with acute lymphoblastic leukemia were lower and showed dynamic changes.Age and family emotional support were continuing factors influencing quality of life.Medical staff should take targeted interventions according to the characteristics of the quality of life of children at different ages,and guide and help parents and children to establish good family emotional support and improve their quality of life.

关 键 词：白血病 儿童 化疗 生活质量 纵向研究 

分 类 号：R73[医药卫生—肿瘤]