MRI弥散张量成像各项异性分数定量评估胶质瘤Ki-67标记指数的价值  

Quantitative Evaluation of Ki-67 Marking Index of Glioma by MRI Diffusion Tensor Imaging Anisotropic Fractions

作　　者：丁治民 翟建[1] 陈基明[1] 俞咏梅[1] 张峥嵘[1] DING Zhi-min(Department of Radiology,the First Affiliated Hospital of Wannan Medical College,Wuhu 241001,China)

机构地区：[1]皖南医学院弋矶山医院影像中心

出　　处：《牡丹江医学院学报》2019年第6期14-17,共4页Journal of Mudanjiang Medical University

基　　金：皖南医学院中青年科研基金(WK2011F11);皖南医学院校重点项目科研基金(WK2019ZF05);安徽省高等学校省级质量工程虚拟仿真实验教学项目(2018xfsyxm054)

摘　　要：目的利用弥散张量成像(diffusion tensor imaging,DTI)的各向异性分数(fractional anisotropy,FA)定量评估胶质瘤细胞核增殖相关抗原标记指数(Ki-67 labeling index,Ki-67 LI)的价值。方法搜集2012年1月至2019年5月间在我院就诊且经手术病理证实的40例胶质瘤患者,术前完善常规头颅MRI平扫、增强及DTI检查,利用基于ADW4.4工作站的Functool 2.0软件测量肿瘤实性组织FA值。通过免疫组化检测术后肿瘤组织的Ki-67 LI表达水平,并分为低Ki-67 LI组(≤10%)和高Ki-67 LI组(>10%),FA值与Ki-67 LI间的相关性分析行Spearman相关检验,低、高Ki-67 LI组间FA值的差异比较行Mann-Whitney U检验。结果胶质瘤FA值[0.1168(0.0154~0.7885)]与Ki-67 LI[16%(2%~40%)]呈负相关(r=-0.783,P<0.001);低Ki-67 LI组胶质瘤的FA值[0.1610(0.0760~0.7885)]与高Ki-67 LI组的FA值[0.0683(0.0154~0.1645)]差异有统计学意义(z=-3.192,P<0.001);ROC曲线下面积为0.859,FA值鉴别胶质瘤低、高Ki-67 LI的敏感度、特异度分别为83.6%、75.7%。结论DTI定量参数FA值与胶质瘤Ki-67 LI关系密切相关,利用FA值定量评估胶质瘤Ki-67 LI具有可行性。Objective To study the value of fractional anisotropy(FA)derived from diffusion tensor imaging(DTI)for quantitative evaluation of Ki-67 labeling index(Ki-67 LI)in glioma.Methods 40 patients with pathological diagnoses of glioma who underwent preoperative conventional and enhanced MRI and DTI were enrolled in this retrospective study.The FA value were calculated from manually drawn ROIs by using software of Functool 2.0 of ADW4.4 workstation.The expression of the marker of Ki-67 LI was recorded by immunohistochemical staining,the patients were divided into low Ki-67 LI(≤10%)group and high Ki-67 LI(>10%)group according to the Ki-67 expression difference.The FA value and Ki-67 LI were acquired and analyzed using the Spearman correlation test.The FA values were compared between low(≤10%)and high(>10%)Ki-67 LI group with Mann-Whitney U test,receiver operating characteristic curves was performed to evaluate the diagnostic value.Results The FA value[0.1168(0.0154~0.7885)]was significantly negatively correlated with Ki-67 LI[16%(2%~40%)](r=-0.783,P<0.001),The FA value showed significantly difference between the low Ki-67 LI group[0.1610(0.0760~0.7885)]and the high Ki-67 group[0.0683(0.0154~0.1645)](z=-3.192,P<0.001).The AUC of most predictive FA value differentiated low and high Ki-67 LI was 0.859,sensitivity was 83.6%and specificity was 75.7%.Conclusion The FA values of DTI are closely related to the expression levels of Ki-67.FA value can be used for quantitative evaluation of Ki-67 LI in glioma.

关 键 词：胶质瘤 弥散张量成像 各向异性分数 KI-67 

分 类 号：R739.41[医药卫生—肿瘤]