组织器官损伤修复和再生研究进展  

Advances in Tissue Repair and Regeneration

作　　者：孟曦男 许静秀 徐素宏 MENG Xinan;XU Jingxiu;XU Suhong(Zhejiang University-Center of Stem Cell and Regenerative Medicine,Hangzhou 310000,China;Zhejiang University-University of Edinburgh Institute,Haining 314400,China)

机构地区：[1]浙江大学医学院干细胞和再生医学中心,杭州310000 [2]浙江大学-爱丁堡大学联合学院,海宁314400

出　　处：《中国细胞生物学学报》2019年第9期1680-1689,共10页Chinese Journal of Cell Biology

基　　金：国家自然科学基金面上项目(批准号:31671522)资助的课题~~

摘　　要：组织器官损伤修复和再生是生命科学领域最为复杂和重要的科学问题之一,任何组织器官都能快速响应损伤,通过内源性基因转录调控改变多种细胞命运属性实现创伤的修复与再生。绝大部分人体组织器官都不具备完美再生能力,然而,进化早期的许多动物以及绝大部分植物具有强大修复和再生能力。经年来,通过对这些模式生物的研究,随着单细胞测序技术的发展,通过遗传示踪、活体显微实时成像,对组织器官再生的关键细胞及其发生调控过程的认识有了显著的进步。该综述将针对损伤修复和再生关键细胞来源、损伤后基因转录调控以及快速损伤应激能力进行简单总结。由于篇幅有限,非常抱歉不能涵盖损伤修复和再生领域的所有研究。Tissue repair and regeneration is one of the complicated biological processes and important biomedical questions in the life science.Rapid wound response can be found in any tissue or organ,that changes a variety of cell fate properties to achieve wound repair and regeneration by triggers endogenous gene transcriptional regulation.Most human tissues and organs do not have the ability to regenerate lost one,however,many animals in early evolutionary,as well as most plants,have strong regenerative capabilities.Through the study of different model organisms,with the development of single-cell sequencing technology,through genetic tracing and in vivo imaging,we are starting to understand the key cell types and underling molecular and cellular mechanism during the tissue regeneration.This review will provide a brief summary of the key cell sources of wound repair and regeneration,post-injury gene transcriptional regulation,and rapid wound stress.Due to limited space,we are unable to cover all the research studies in the field of tissue repair and regeneration.

关 键 词：组织损伤修复 再生细胞来源 信号通路 钙信号 三磷酸腺苷 活性氧 

分 类 号：R73[医药卫生—肿瘤]