胰岛素样生长因子1在慢性坐骨神经痛患者血清中的表达及临床意义  

Expression and clinical significance of insulin-like growth factor 1 in serum of patients with chronic sciatica

作　　者：薄靳华[1] 郑旭[1] 蒋忠[1] Jin-hua Bo;Xu Zheng;Zhong Jiang(Department of Anesthesiology,Drum Tower Hospital,Medical School of Nanjing University,Nanjing,Jiangsu 210008,China)

机构地区：[1]南京大学医学院附属鼓楼医院麻醉科

出　　处：《中国现代医学杂志》2019年第24期75-77,共3页China Journal of Modern Medicine

基　　金：国家自然科学基金(No:81600958)

摘　　要：目的探讨胰岛素样生长因子-1(IGF-1)在长期坐骨神经痛觉患者血清中的表达及其临床意义。方法选取2016年2月—2016年5月于南京大学医学院附属鼓楼医院住院治疗的慢性腰疼患者21例作为慢性疼痛组,选取同期该院健康体检者21例作为对照组。采用酶联免疫吸附试验检测两组血清IGF-1水平,并对疼痛进行评分。结果慢性疼痛组视觉模拟评分高于对照组(P<0.05),慢性疼痛组血清IGF-1水平高于对照组(P<0.05)。结论血清IGF-1水平升高可能与慢性坐骨神经痛的发生、发展有关。Objective To investigate the expression of insulin-like growth factor-1(igf-1)in serum in patients with chronic sciatic nerve pain and its clinical significance.Methods The expression of IGF-1 was tested by enzyme linked immunosorbent assay in 21 patients with chronic sciatic nerve pain and 21 healthy people of physical check-up.The experiment evaluated the pain degree of everyone by VAS.Results The pain degree in the group of chronic sciatic nerve pain(4.95±1.07)significantly increased compared to health check group(P<0.05).The expression level of IGF-1 in the group of chronic sciatic nerve pain apparently higher than in health check group(P<0.05).Conclusions The expression level of IGF-1 increased in serum may be associated with the development of chronic sciatic pain.

关 键 词：坐骨神经痛 胰岛素样生长因子Ⅰ 慢性病 

分 类 号：R745.42[医药卫生—神经病学与精神病学]