降钙素原在肿瘤患者早期细菌血流感染诊断与疗效评估中的价值  

The Value of Procalcitonin in the Diagnosis and Therapeutic Evaluation of Early Bacterial Bloodstream Infection in Patients with Cancer

作　　者：李佩章[1] 庞乃奇 张云[1] 李春蓉[1] 舒宏[1] 王英[1] LI Pei-zhang;PANG Nai-qi;ZHANG Yun;LI Chun-rong;SHU Hong;WANG Ying(Department of Clinical Laboratory,Affiliated Tumor Hospital,Guangxi Medical University,Nanning,Guangxi,530021 China)

机构地区：[1]广西医科大学附属肿瘤医院检验科

出　　处：《系统医学》2019年第21期142-144,共3页Systems Medicine

基　　金：广西卫计委科研课题（Z2014587）

摘　　要：目的探讨降钙素原(procalcitonin,PCT)对肿瘤患者细菌血流感染早期诊断与疗效评估的临床价值。方法选取2017年1月—2018年6月在广西医科大学附属肿瘤医院住院治疗的153例肿瘤患者为研究对象,根据血培养结果分为观察组(83例)和对照组(70例),对比和分析两组患者PCT、白细胞计数(WBC)及体温的变化情况;观察组治疗后根据血培养结果分有效组与无效组,组内对比治疗前后PCT水平。结果观察组PCT均值为(16.36±6.13)ng/mL,对照组PCT均值为(0.41±0.25)ng/mL,两组数据间比较差异有统计学意义(t=36.33,P<0.05);而观察组WBC值为(13.31±4.63)×10^9/L,对照组WBC值为(12.89±4.55)×10^9/L;观察组体温为(38.37±0.66)℃,对照组体温为(38.12±0.53)℃,两组间在WBC及体温水平的对照差异无统计学意义(t=0.19,P>0.05;t=0.11,P>0.05)。降钙素原诊断细菌性血流感染的敏感度为93.98%,特异度为87.14%。治疗有效组PCT水平较治疗前明显降低(t=28.91,P<0.05),无效组治疗前后PCT水平差异无统计学意义(t=1.32,P>0.05)。结论血清PCT水平对肿瘤患者细菌血流感染早期诊断与疗效评估有较高的临床价值。Objective To investigate the clinical value of procalcitonin(PCT) in early diagnosis and therapeutic evaluation of bacterial bloodstream infection in tumor patients. Methods A total of 153 patients with tumors who were hospitalized in the Affiliated Tumor Hospital of Guangxi Medical University from January 2017 to June 2018 were enrolled.According to the results of blood culture, they were divided into observation group(83 cases) and control group(70 cases). The changes of PCT, white blood cell count(WBC) and body temperature were analyzed in the two groups. The observation group was divided into the effective group and the ineffective group according to the blood culture results after treatment, and the PCT level before and after the treatment was compared in the group. Results The mean PCT value of the observation group was(16.36±6.13)ng/mL, and the mean PCT of the control group was(0.41±0.25)ng/mL.The difference between the two groups was statistically significant(t=36.33, P<0.05). The WBC value of the observation group was(13.31±4.63)×109/L, and the WBC value of the control group was(12.89±4.55)×109/L. The body temperature of the observation group was(38.37±0.66)°C, and the body temperature of the control group was(38.12±0.53)°C. There was no significant difference in WBC and body temperature between the two groups(t=0.19, P>0.05, t=0.11, P>0.05).The sensitivity of procalcitonin for the diagnosis of bacterial bloodstream infection was 93.98% and the specificity was 87.14%. The PCT level in the therapeutically effective group was significantly lower than that before treatment(t=28.91, P<0.05). There was no statistically significant difference in PCT levels between the ineffective group before and after treatment(t=1.32,P>0.05). Conclusion Serum PCT level is early in the bacterial infection of tumor patients. Diagnosis and efficacy evaluation have high clinical value.

关 键 词：降钙素原 细菌血流感染 早期诊断 疗效评估 

分 类 号：R730.43[医药卫生—肿瘤]