冷冻消融联合免疫治疗实体肿瘤研究进展  

Research progress of cryoablation combined with immunotherapy for solid tumors

作　　者：孟亮亮 张肖[1] 张啸波[1] 吴斌[1,2] 李竞 何晓锋 魏颖恬[1] 张欣 肖越勇[1] MENG Liangliang;ZHANG Xiao;ZHANG Xiaobo;WU Bin;LI Jing;HE Xiaofeng;WEI Yingtian;ZHANG Xin;XIAO Yueyong(Department of Radiology,Chinese PLA General Hospital,Beijing 100853,China;Department of Radiology,Hospital of Beijing Armed Police Force,Beijing 100027,China)

机构地区：[1]中国人民解放军总医院放射诊断科,北京100853 [2]武警北京市总队医院医学影像科,北京100027

出　　处：《中国介入影像与治疗学》2019年第12期759-762,共4页Chinese Journal of Interventional Imaging and Therapy

基　　金：国家自然科学基金面上项目(81271674)

摘　　要：冷冻消融不仅导致肿瘤细胞坏死和凋亡,还可将肿瘤来源自身抗原释放到血液循环中,刺激宿主免疫系统发生针对原发性和转移性肿瘤的抗肿瘤免疫效应。肿瘤免疫治疗通过主动或被动改变宿主免疫系统功能达到治疗肿瘤目的。本文对冷冻消融联合免疫治疗实体肿瘤的效果与机制研究进展进行综述。Cryoablation can not only lead to tumor cell necrosis and apoptosis, but also release tumor-derived autoantigens into the blood circulation, stimulate the host’s immune system to produce anti-tumor immune effects against primary and metastatic tumors. Tumor immunotherapy aims to treat tumors by actively or passively changing the function of host immune system. The research advances of cryoablation combined with immunotherapy for solid tumors were reviewed in this article.

关 键 词：肿瘤 导管消融术 冷冻疗法 免疫治疗 

分 类 号：R730.5[医药卫生—肿瘤] R815[医药卫生—临床医学]