Angle of Attack between Blood Flow and Mitral Valve Leaflets in Hypertrophic Obstructive Cardiomyopathy: An In Vivo Multipatient CT-based FSI Study  

作　　者：Long Deng Xueying Huang Heng Zuo Yuan Zheng Chun Yang Yunhu Song Dalin Tang 

机构地区：[1]Department of Cardiac Surgery,Fuwai Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,China. [2]School of Mathematical Sciences,Fujian Provincial Key Laboratory of Mathematical Modeling and High-Performance Scientific Computation,Xiamen University,Xiamen,Fujian,China. [3]Department of Mathematical Sciences,Worcester Polytechnic Institute,MA,USA. [4]School of Mathematical Sciences,Sichuan Normal University,Chengdu,Sichuan,China. [5]China Information Technology Designing&Consulting Institute Co.,Ltd.,Beijing,China. [6]School of Biological Science&Medical Engineering,Southeast University,Nanjing,China.

出　　处：《Computer Modeling in Engineering & Sciences》2018年第8期115-125,共11页工程与科学中的计算机建模（英文）

基　　金：The authors would like to acknowledge the research support from Natural Science Foundation of Fujian Province of China(Grant No.2017J01009);Fundamental Research Funds for the Central Universities(Grant No.20720180004);National Heart,Lung and Blood Institute grants R01 HL089269,and National Sciences Foundation of China(Grant No.11672001,81571691).

摘　　要：The mechanisms of systolic anterior motion(SAM)of the mitral valve in hypertrophic obstructive cardiomyopathy(HOCM)remain unclear.To investigate the angle of attack between blood flow and mitral valve leaflets at pre-SAM time point,patient-specific CT-based computational models were constructed for 5 patients receiving septal myectomy surgery to obtain pre-and post-operative 2D vector flow mapping.The comparisons between pre-and post-operative angles of attack based on 2D vector flow mapping of 5 patients were performed.It was found that there was no statistically significant difference between pre-and post-operative angles of attack(61.1±t wa o vs.56.2±56.o,p=0.306,n=5).Therefore,we propose that the angle of attack might not play an important role in the initiation of SAM.

关 键 词：HYPERTROPHIC OBSTRUCTIVE CARDIOMYOPATHY SYSTOLIC anterior motion mitralvalve LEAFLETS computational model angle of attack 

分 类 号：R54[医药卫生—心血管疾病]