两种皮肤防护剂防治头颈部恶性肿瘤患者放射性皮肤损伤疗效对比  

Analysis of the Therapeutic Effect of Two Skin Protectants in the Prevention and Treatment of Radiation-induced Skin Injury in Patients with Head and Neck Malignancies

作　　者：王楠 Wang Nan(Department of Radiotherapy,Dalian Municipal Central Hospital,Dalian City,Liaoning 116000,China)

机构地区：[1]大连市中心医院放疗科

出　　处：《中国烧伤创疡杂志》2019年第6期391-393,399,共4页The Chinese Journal of Burns Wounds & Surface Ulcers

摘　　要：目的对比观察两种皮肤防护剂对头颈部恶性肿瘤患者放射性皮肤损伤的防治效果。方法回顾性分析2016年8月至2018年8月大连市中心医院放疗科收治的57例采用放射治疗皮肤防护剂(利肤宁,设为试验组)与53例采用三乙醇胺乳膏(设为对照组)预防放射性皮肤损伤的行放射治疗的头颈部恶性肿瘤患者的病历资料,两组患者除外用药不同外,其他治疗方法均相同,对比两组患者放射治疗期间放射性皮肤损伤程度及不同放射剂量时放射性皮肤损伤发生情况。结果(1)放射治疗1周后,试验组患者中皮肤出现1级损伤者18例、2级损伤者37例、3级损伤者2例,对照组患者中皮肤出现1级损伤者10例、2级损伤者29例、3级损伤者13例、4级损伤者1例,两组对比,P<0.05,差异具有统计学意义。(2)试验组患者在放射剂量为20 Gy以下时均未出现皮肤损伤;在放射剂量为20~40 Gy时,有18例患者出现皮肤损伤;在放射剂量为40 Gy以上时,有39例患者出现皮肤损伤。对照组患者在放射剂量为20 Gy以下时,有1例患者出现皮肤损伤;在放射剂量为20~40Gy时,有29例患者出现皮肤损伤;在放射剂量为40 Gy以上时,有23例患者出现皮肤损伤。两组患者接受不同放射剂量时皮肤损伤发生情况对比,P<0.05,差异具有统计学意义。结论利肤宁可有效延长头颈部恶性肿瘤患者放射治疗期间放射性皮肤损伤的发生时间,降低皮肤损伤程度,疗效显著,临床应用价值较高。Objective To explore the effects of two skin protectants in preventing and treating the radiationinduced skin injury in patients with head and neck malignancies.Methods The medical records of 57 patients that used a skin protectant-Lifuning(experiment group)and 53 patients that used Triethanolamine Cream(control group)to prevent radiation-induced skin injury during the radiotherapy in the Department of Radiotherapy of Dalian Municipal Central Hospital between August 2016 and August 2018 were retrospectively analyzed.In the two groups,except the two different skin protectants,all the other treatments were same.The degree of radiation-induced skin injury and the occurrence of radiation-induced skin injury under different radiation doses during the radiotherapy were compared between the two groups.Results(1)After one week of radiotherapy,in the experiment group,18 patients developed gradeⅠskin injury,37 patients developed gradeⅡskin injury and 2 patients developed gradeⅢskin injury,while in the control group,10 patients developed gradeⅠskin injury,29 patients developed gradeⅡskin injury,13 patients developed gradeⅢskin injury and 1 patient developed gradeⅣskin injury,between which the difference was statistically significant(P<0.05).(2)In the experiment group,no patient developed skin injury when the radiation dose was under 20 Gy,while when the radiation dose was 20-40 Gy,18 patients developed skin injury,and when the radiation dose was above 40 Gy,skin injury appeared in 39 patients.In contrast,in the control group one patient developed skin injury under the radiation dose of less than 20 Gy,29 patients developed skin injury when the radiation dose was 20-40 Gy and 23 patients developed skin injury when the radiation dose was above 40 Gy.The comparison between the two groups in terms of the occurrence of skin injury under different radiation doses showed a statistically significant difference,P<0.05.Conclusion The skin protectant Lifuning can effectively delay the appearance of radiation-induced skin

关 键 词：头颈部恶性肿瘤 利肤宁 三乙醇胺乳膏 放射性皮肤损伤 疗效 

分 类 号：R73[医药卫生—肿瘤]