铁死亡与自噬在疾病中的研究进展  

Research progress of iron death and autophagy in diseases

作　　者：彭霞 方聪聪[1] 徐宇明 姚宝珍[1] PENG Xia;FANG Congcong;XU Yuming(Department of Pediatrics,Renmin Hospital of Wuhan University,Hubei Province,Wuhan 430060,China)

机构地区：[1]武汉大学人民医院儿科

出　　处：《疑难病杂志》2019年第12期1284-1287,1292,共5页Chinese Journal of Difficult and Complicated Cases

摘　　要：铁死亡是一种铁依赖的、以谷胱甘肽过氧化物酶4活性丧失、脂质过氧化物沉积为特点的细胞死亡方式。自噬是一种高度保守的、用于降解和回收利用生物大分子或受损细胞器的过程。当自噬过度激活时,也会引起细胞的自噬性死亡。文章就铁死亡与自噬的相互关系及其在神经系统疾病、循环系统疾病和肿瘤中的研究进展作一综述,以期加深对铁死亡及自噬关系的认识。Iron death is an iron-dependent cell death mode characterized by loss of glutathione peroxidase 4 activity and lipid peroxide deposition.Autophagy is a highly conservative process used to degrade and recycle biological macromolecules or damaged organelles.When autophagy is overactivated,autophagic death of cells is also caused.This article reviews the relationship between iron death and autophagy and its research progress in nervous system diseases,circulatory system diseases and tumors in order to deepen the understanding of the relationship between iron death and autophagy.

关 键 词：铁死亡 自噬 相互关系 铁离子 

分 类 号：R73[医药卫生—肿瘤]