整合素α2基因807位点基因多态性与缺血性脑卒中的相关性的Meta分析  

Correlation between polymorphism at locus 807 of integrin α2 gene and ischemic stroke:a meta-analysis

作　　者：杨锡彤 徐弘扬 马蓉 王光明 YANG Xi-tong;XU Hong-yang;MA Rong;WANG Guang-ming(Genetic Testing Center,the First Affiliated Hospital of Dali University,Dali 671000,China;Department of Neurology,the First Affiliated Hospital of Dali University,Dali 671000,China)

机构地区：[1]大理大学第一附属医院基因检测中心,云南省大理市671000 [2]大理大学第一附属医院神经内科,云南省大理市671000

出　　处：《广西医学》2019年第21期2755-2763,共9页Guangxi Medical Journal

基　　金：国家自然科学基金(81360206);云南省中青年学术技术带头人后备人才基金(2014HB025);云南省教育厅科学研究基金(2019J0775)

摘　　要：目的系统评价整合素α2基因807位点基因多态性与缺血性脑卒中的相关性。方法计算机检索Cochrane Library、PubMed及中国知网、维普、万方数据库,搜集关于整合素α2基因807位点基因多态性与缺血性脑卒中的相关性的病例对照研究。对纳入文献进行筛选及质量评价后,采用RevMan 5.3软件进行Meta分析。结果共纳入13篇文献,4 342例研究对象。Meta分析结果显示,与携带C等位基因者比较,携带T等位基因者发生缺血性脑卒中的风险升高(均P<0.05);在纯合子、杂合子模型中,与携带CC基因型者比较,携带TT、CT基因型者发生缺血性脑卒中的风险升高(均P<0.05);在隐性基因模型中,与携带CT、CC基因型者比较,携带TT基因型者发生缺血性脑卒中的风险升高(P<0.05);在显性基因模型中,携带CT、TT基因型者发生缺血性脑卒中的风险与携带CC基因型者比较差异无统计学意义(P>0.05)。亚组分析结果显示,在等位基因模型、纯合子模型、杂合子模型和隐性基因模型中,中国人群整合素α2基因807位点多态性与缺血性脑卒中发病均存在相关性(均P<0.05);在5种基因模型中,西方人群整合素α2基因807位点多态性与缺血性脑卒中均无相关性(均P>0.05)。结论整合素α2基因807位点基因多态性与缺血性脑卒中易感性有关,携带T等位基因可能是罹患缺血性脑卒中的危险因素,而中西方人群该位点多态性对其缺血性脑卒中易感性的影响存在差异。Objective To systematically evaluate the correlation between polymorphism at locus 807 of integrin α2 gene and ischemic stroke.Methods A computer-based retrieval was performed in Cochrane Library,PubMed,CNKI,VIP and Wangfang databases,and case-control studies about the correlation between polymorphism at locus 807 of integrin α2 gene and ischemic stroke were searched and collected.RevMan 5.3 software was used to conduct a Meta-analysis after screening enrolled literature and quality evaluation.Results Thirteen studies consisting of 4 342 subjects were enrolled.Meta-analysis results revealed that the individuals carrying allele T had a higher risk of developing ischemic stroke in comparison with the individuals carrying allele C(all P<0.05);in homozygous model and heterozygous model,the risk of ischemic stroke in the individuals carrying genotype TT or CT was higher than that in the individuals carrying genotype CC(all P<0.05);in recessive gene model,the risk of ischemic stroke in the individuals carrying genotype TT was higher compared to the individuals carrying genotype CT or CC(P<0.05);in dominant gene model,there was no statistically significant difference in the risk of ischemic stroke between the individuals carrying genotype CT or TT and the individuals carrying genotype CC(P>0.05).The subgroup analysis results showed that there was a correlation between the polymorphism at locus 807 of integrin α2 gene and the occurrence of ischemic stroke in Chinese population in the allele model,homozygous model,heterozygous model and recessive gene model(all P<0.05);in all five gene models,there were no correlations between the polymorphism at locus 807 of integrin α2 gene and ischemic stroke in western population(all P>0.05).Conclusion The polymorphism at locus 807 of integrin α2 gene is correlated with the susceptibility to ischemic stroke,and carrying allele T may be a risk factor of suffering from ischemic stroke,whereas there is a difference between Chinese and western population in the effect of polymorphism

关 键 词：缺血性脑卒中 整合素Α2 基因多态性 位点807 相关性 META分析 

分 类 号：R743.3[医药卫生—神经病学与精神病学]