疏血通注射液联合奥扎格雷对急性脑梗死病人神经功能及脑血流指标的影响  

Influences of Shuxuetong Injection Combined with Ozagrel on Nerve Function and Cerebral Blood Flow Index in Patients with Acute Cerebral Infarction

作　　者：吴秋义[1] 周寅[1] 陈科春 郭刚[1] 施惠敏[1] WU Qiuyi;ZHOU Yin;CHEN Kechun;GUO Gang;SHI Huimin(First People's Hospital of Zhangjiagang Jiangsu Province,Zhangjiagang 215600,Jiangsu,China)

机构地区：[1]江苏省张家港市第一人民医院

出　　处：《中西医结合心脑血管病杂志》2019年第21期3292-3295,共4页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

基　　金：国家“十二五”科技重大专项课题(No.2014X09201022-010)

摘　　要：目的观察疏血通注射液联合奥扎格雷对急性脑梗死(ACI)病人神经功能及脑血流指标的影响。方法选取2014年12月—2017年6月江苏省张家港市第一人民医院收治的ACI病人110例。采用乱数表法将病人分为观察组和对照组,各55例。对照组采用奥扎格雷治疗,观察组在对照组基础上联合疏血通注射液治疗,比较两组病人的临床疗效,同时比较两组病人治疗前后美国国立卫生院卒中量表(NIHSS)评分以及脑血流指标(最大峰值流速、平均血流速度、舒张末血流速度、血管搏动指数及血管阻力指数),并观察治疗过程中出现的不良反应。结果治疗后观察组总有效率为90.91%,明显高于对照组的70.91%(P<0.05)。与治疗前相比,治疗后两组病人NIHSS评分均有改善(P<0.05),且治疗后观察组病人改善幅度明显优于对照组(P<0.05);两组治疗后最大峰值流速、平均血流速度、舒张末血流速度均明显升高(P<0.05),血管搏动指数及血管阻力指数均明显降低(P<0.05),且观察组最大峰值流速、平均血流速度、舒张末血流速度均高于对照组(P<0.05),血管搏动指数及血管阻力指数均低于对照组(P<0.05)。两组不良反应率比较差异无统计学意义(P>0.05)。结论疏血通注射液联合奥扎格雷可有效改善ACI病人的神经功能和脑血流指标,提高临床疗效。Objective To investigate the effect of Shuxuetong injection combined with ozagrel on nerve function and cerebral blood flow index in patients with acute cerebral infarction(ACI).Methods One hundred and ten patients with ACI who were treated in our hospital from December 2014 to June 2017 were selected,and the patients were divided into the observation group and the control group according to the random table method,with 55 cases in each group.The patients in the control group were treated with ozagreland the patients in the observation group were treated with Shuxuetong injection on the basis of the control group.The clinical efficacy of the two groups was compared.Meanwhile,the National Institutes of Health Stroke Scale(NIHSS)score and cerebral blood flow indexes(maximum peak flow velocity,mean blood flow velocity,end diastolic blood flow velocity,vascular pulsatility index and vascular resistance index)were compared between two groups before and after treatment,and the adverse reactions in the course of treatment were observed.Results After treatment,the total effective rate of the observation group was 90.91%,which was significantly higher than that of the control group(70.91%,P<0.05).Compared with that before treatment,the NIHSS scores of the two groups were improved after treatment,and that in the observation group was significantly higher than that of the control group(P<0.05).After treatment,the maximal peak velocity,mean blood flow velocity and end diastolic blood flow velocity of two groups were significantly increased,and the vascular pulsatility index and vascular resistance index were significantly decreased(P<0.05).The maximal peak velocity,mean blood flow velocity,and end diastolic blood flow velocity of the observation group were higher than those in the control group,and the vascular pulsatility index and vascular resistance index were lower than those in the control group(P<0.05).There was no significant difference in the rate of adverse reaction between two groups(P>0.05).Conclusion Shuxuetong i

关 键 词：急性脑梗死 疏血通注射液 奥扎格雷 神经功能 脑血流指标 

分 类 号：R743.1[医药卫生—神经病学与精神病学] R289.5[医药卫生—临床医学]