心脏仿真模型外层材料配方研制及实验优化  

Study on the formulation of the outer layer material of the heart simulation model and its experimental optimization design

作　　者：张超慧[1] 关喆[1] 匡宝平[1] 申笑颜[1] 黄和[1] ZHANG Chaohui;GUAN Zhe;KUANG Baoping;SHEN Xiaoyan;HUANG He(Shenyang Medical College,Shenyang 110034,China)

机构地区：[1]沈阳医学院计算机与数理教学部

出　　处：《实验室研究与探索》2019年第10期40-44,共5页Research and Exploration In Laboratory

基　　金：教育部高等学校教学指导委员会教学研究课题(DWJZW201701zx-3);辽宁省教育评价协会教学改革与教育质量评价课题(PJHYYB17213);沈阳市科技创新智库决策咨询课题(2018118);沈阳医学院大学生科研课题(20170902)

摘　　要：医学仿真中的外层组织材质在模拟临床试验、医学科研及教学演示中具有重要的情景再现作用。介绍的一种心脏仿真模型外层材料配方研究,根据区域特点不同,采用了相应实验优化方案。通过正交试验选取了液体硅胶、固化剂、染料用量及固化时间等4个指标对外表面层材质进行了优化考察,从中得到最佳的心脏仿真模型外层材料配制比例。其中,固化时间权重比例影响最为明显,固化剂用量指标权重影响次之,液体硅胶和染料用量权重影响最小。通过结果满意度排序,最佳配比液体硅胶为100 m L、固化剂为2 m L、染料为17 m L、固化时间为2 h。内表面层材质制备由已有的正交试验实验数据支撑,摸索为单因素变量考查,最佳条件为干燥时间2 h,固化剂量2. 5 m L,液体硅胶量100 m L效果最好。组织功能区域二次修饰经对比实验发现:样品干燥15 min后进行的二次厚涂覆修饰效果最好。Medical simulation provides reliable clinical program verification and experience accumulation for medical staff. The simulation of outer tissue materials in simulation plays an important role in the simulation of clinical trials,medical scientific research and teaching demonstration. Therefore,a kind of outer material formula of heart simulation model is studied in this paper. According to the different requirements of the region,the corresponding experimental optimization scheme is adopted. The materials of outer surface layer were optimized and investigated by orthogonal test,four factors,liquid silica gel,curing agent,amount of dye and curing time,were selected for index analysis and verification. The best proportions of the outer materials in the heart simulation model were obtained. Among them,the weight ratio of curing time is the most obvious,the weight of curing agent dosage is the second,and the weight of liquid silica gel and dye dosage is the least. The optimal proportion of liquid silica gel is 100 m L,the curing agent is 2 m L,the dye is 17 m L and the curing time is 2 h. Due to the support of orthogonal experiment data,each condition was investigated as a single factor variable. The optimum conditions are drying time 2 h,curing agent dosage 2. 5 m L,and liquid silica gel amount 100 m L. The second modification of the tissue functional area was compared with that of the sample after drying the 15 min,and the effect of the thick coating was good.

关 键 词：心脏仿真 外层材料制备 多方面分析 正交试验 实验方案优化 

分 类 号：R331[医药卫生—人体生理学]