干眼的再生疗法研究进展  

Regenerative medicine in dry eye

作　　者：张梦瑶 汪水风 邵毅[1] ZHANG Meng-Yao;WANG Shui-Feng;SHAO Yi(Department of Ophthalmology,the First Affiliated Hospital of Nanchang University,Nanchang 330006,Jiangxi Province,China)

机构地区：[1]南昌大学第一附属医院眼科

出　　处：《眼科新进展》2019年第12期1192-1196,共5页Recent Advances in Ophthalmology

基　　金：国家自然科学基金资助(编号:81460092、81400372、81660158);江西省远航工程(编号:2014022);江西省自然科学基金重大项目(编号:20161ACB21017);江西省自然科学基金(编号:20151BAB215016);江西省重点研发项目(编号:20151BBG702-23)~~

摘　　要：干眼是一种与泪液和眼表组织病变相关的多诱因疾病。目前干眼的主要治疗是对症治疗,包括眼部润滑和消炎,但是有局限性。细胞凋亡在干眼发病机制中的作用逐渐被发现,生物学最新的研究方向是使病变组织再生,特别是间充质干细胞,其具有多重性、营养性和免疫调节性。本文对干眼再生疗法最新研究进展进行综述。Dry eye syndrome is multi-inductive diseases associated with tear and ocular surface lesion.At present,the main treatment of dry eye is symptomatic treatment,including eye lubrication and anti-inflammatory,but there are some limitations.The role of apoptosis in the pathogenesis of dry eye has been discovered year by year.The latest research direction of biology is to make pathological tissue regenerate,especially mesenchymal stem cells,with multiple,nutritive and immunomodulatory properties.We will review the latest research status,as well as the latest progress and results of these promising treatments in this field of pathology.

关 键 词：间充质干细胞 同种异体细胞疗法 生长因子 泪腺 干眼 干燥性角膜结膜炎 再生医学 

分 类 号：R777.34[医药卫生—眼科]