急性缺血性脑卒中患者血清A-FABP、CXCL12水平变化及临床意义  

Changes and clinical significances of serum A-FABP and CXCL12 levels of patients with acute ischemic stroke

作　　者：柴玉梅[1] 薛瑶[1] 师仰宏[1] 康林娥[1] CHAI Yu-mei;XUE Yao;SHI Yang-hong(Department of Neurology,Yulin First Hospital,Yulin Shaanxi 719000,China)

机构地区：[1]榆林市第一医院神经内科

出　　处：《临床和实验医学杂志》2019年第24期2643-2646,共4页Journal of Clinical and Experimental Medicine

基　　金：陕西省科技厅社会发展科技攻关项目(编号:2016SF-248)

摘　　要：目的 探讨血清脂肪细胞型脂肪酸结合蛋白(A-FABP)、趋化因子CXCL12水平在急性缺血性脑卒中的变化及临床意义。方法 回顾性选取2017年8月至2018年8月榆林市第一医院收治的急性缺血性脑卒中患者100例作为病例组,另回顾性选取同期榆林市第一医院收治的健康体检人员100例作为健康组,统计分析两组人员的血清AFABP、CXCL12水平,以及病例组不同临床和病理特征、预后患者的血清A-FABP、CXCL12水平,并分析病例组患者病变程度及预后与血清A-FABP、CXCL12水平的相关性。结果 病例组患者的血清A-FABP、CXCL12水平均显著高于健康组,差异具有统计学意义(P <0. 05)。病例组患者的梗死面积> 4 cm^2、美国国立卫生院神经功能缺损量表(NIHSS)评分> 15分、格拉斯哥昏迷(GCS)评分> 8分患者的血清A-FABP、CXCL12水平分别显著高于梗死面积≤4 cm2、NIHSS评分≤15分、GCS评分≤8分患者,差异具有统计学意义(P <0. 05),但不同性别、年龄、高血压史患者的血清A-FABP、CXCL12水平之间的差异均无统计学意义(P> 0. 05)。病例组100例患者中,预后良好77例,预后不良23例,预后良好率为77. 0%,其中病例组预后良好组患者的血清A-FABP、CXCL12水平均显著低于预后不良组,差异具有统计学意义(P <0. 05)。病例组患者梗死面积、NIHSS评分、GCS评分、改良Rankin量表(MRS)评分与血清A-FABP、CXCL12水平均呈显著的正相关关系(P <0. 05)。结论 血清A-FABP、CXCL12水平在急性缺血性脑卒中患者中升高,检测急性缺血性脑卒中患者的血清A-FABP、CXCL12水平能够将有效依据提供给临床的诊断、病变严重程度判定及预后评估工作。Objective To investigate the changes and clinical significances of serum A-FABP and CXCL12 levels of patients with acute ischemic stroke.Methods 100 cases of patients with acute ischemic stroke in Yulin First Hospital from August 2017 to August 2018 were selected retrospectively.These patients were selected as case group,and 100 cases of healthy people were retrospectively selected as health group.The serum A-FABP,CXCL12 levels of the two groups,different clinical and pathological characteristics of the case group,and the serum A-FABP,CXCL12 levels of patients with different prognosis were statistically analyzed.The correlations between degrees of pathological changes and prognosis and levels of serum A-FABP and CXCL12 of the case group were analyzed.Results The serum levels of A-FABP and CXCL12 of the case group were significantly higher than the healthy group,the differences were statistically significant(P<0.05).The levels of serum A-FABP and CXCL12 of patients with infarction area>4 cm^2,National Institutes of health neurological deficit scale(NIHSS)score>15 and Glasgow Coma(GCS)score>8 were significantly higher than patients with infarction area≤4 cm ^2,NIHSS score≤15 and GCS score≤8,the differences were statistically significant(P<0.05),but the differences of levels of serum A-FABP and CXCL12 between patients with different genders,ages and hypertension history were not significant(P>0.05).Among the 100 cases of patients in the case group,77 cases had good prognosis,23 cases had poor prognosis,the good prognosis rate was 77.0%.The serum levels of A-FABP and CXCL12 of patients with good prognosis were significantly lower than patients with poor prognosis,the differences were statistically significant(P<0.05).There were significant positive correlations between infarction area,NIHSS score,GCS score,Modified Rankin scale(MRS)score and serum A-FABP,CXCL12 levels(P<0.05).Conclusion The levels of serum A-FABP and CXCL12 of patients with acute ischemic stroke increases,which can provide effective basis for c

关 键 词：急性缺血性脑卒中 脂肪细胞型脂肪酸结合蛋白 趋化因子 CXCL12 

分 类 号：R73[医药卫生—肿瘤]