肝动脉化疗栓塞联合三维适形放疗在原发性肝癌合并门静脉癌栓患者中的临床效果  

Clinical effect of transcatheter arterial chemoembolization combined with three-dimensional conformal radiotherapy in patients with hepatic carcinoma and portal vein tumor thrombus

作　　者：田云飞[1] 邹嵩[1] 谢可平[1] 余春林 钟宝亮 TIAN Yun-fei;ZOU Song;XIE Ke-ping;YU Chun-lin;ZHONG Bao-liang(Department of Intervention,Ganzhou People’s Hospital,Jiangxi Province,Ganzhou 341000,China)

机构地区：[1]江西省赣州市人民医院介入科

出　　处：《中国当代医药》2019年第33期63-66,共4页China Modern Medicine

基　　金：江西省赣州市指导性科技计划项目(GZ2015ZSF179)

摘　　要：目的探讨肝动脉化疗栓塞联合三维适形放疗在原发性肝癌合并门静脉癌栓患者中的临床效果。方法选取2015年3月~2017年12月我院收治的150例原发性肝癌合并门静脉癌栓患者作为研究对象,根据随机数字表法分为对照组和观察组,每组各75例。对照组患者采取肝动脉化疗栓塞治疗,观察组患者采取肝动脉化疗栓塞联合三维适形放疗进行治疗,观察并比较两组患者的近期、远期疗效与不良反应发生情况。结果观察组患者的疾病缓解(OR)率与疾病控制(DC)率高于对照组,差异均有统计学意义(P<0.05);观察组患者的疾病进展时间短于对照组,1年生存率高于对照组,差异有统计学意义(P<0.05);两组患者的不良反应总发生率比较,差异无统计学意义(P>0.05)。结论肝动脉化疗栓塞联合三维适形放疗治疗原发性肝癌合并门静脉癌栓患者,可以有效提高患者的近期临床治疗效果,提高患者的1年生存率,且不增加不良反应,安全性相对可靠。Objective To investigate the clinical effect of transcatheter arterial chemoembolization combined with three-dimensional conformal radiotherapy in patients with primary hepatic carcinoma and portal vein cancer.Methods A total of 150 patients with primary hepatic carcinoma and portal vein tumor thrombus who treated in our hospital from March 2015 to December 2017 were selected as subjects.By a random number table method,they were divided into the control group and observation group,with 75 cases in each group.In the control group,hepatic arterial chemoembolization was used.The observation group treated with transcatheter arterial chemoembolization combined with three-dimensional conformal radiotherapy.The short and long-term efficacy and adverse reactions of the two groups were observed and compared.Results The rates of disease remission(OR)and disease control(DC)in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).The disease progression in the observation group was shorter than that in the control group,and the 1-year survival rate was higher than that in the control group,with statistical difference(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Transcatheter arterial chemoembolization combined with three-dimensional conformal radiotherapy for patients with primary hepatic carcinoma and portal vein tumor thrombus can effectively improve the short-term effect and the 1-year survival rate,and does not increase adverse reactions,it is relatively safe.

关 键 词：原发性肝癌 门静脉癌栓 肝动脉化疗栓塞 三维适形放疗 

分 类 号：R730.55[医药卫生—肿瘤]