18F-FDG PET/CT延迟显像在肺癌诊断及预后判断中的应用价值  

The Delayed Imaging Application of 18F-FDG PET/CT in the Diagnosis and Prognosis Evaluation of Pulmonary Carcinoma

作　　者：石健[1] 施冬辉[1] 蔡淑华[1] 沈智勇[1] Shi Jian;Shi Donghui;Cai Shuhua;Shen Zhiyong(Department of Radiology,Nantong Tumour Hospital,Nantong,Jiangsu 226361)

机构地区：[1]南通市肿瘤医院影像科

出　　处：《现代医用影像学》2019年第11期2364-2366,2370,共4页Modern Medical Imageology

摘　　要：目的:探讨氟代脱氧葡萄糖正电子发射计算机断层显像(18F-FDG PET/CT)延迟显像在肺癌诊断及判断预后的价值。方法:回顾性分析2013年1月至2014年12月在南通市肿瘤医院住院且接受PET/CT检查的44例肺结节患者临床资料。患者静脉注射18F-FDG造影剂60 min后行早期PET/CT显像,120 min后行延迟PET/CT显像,测定两次显像中病灶最大标准摄取值(SUVmax)。运用接受器工作特性曲线的曲线下面积(area under the receptor operating characteristic curve,AUC)分析比较早期及延迟SUVmax诊断肺结节的诊断效能。1例患者消炎随访、2例进行肺穿刺、41例患者进行手术病理检查。随访恶性肺结节患者手术后的生存状态(健康、转移、死亡)。结果:肺良性结节8例、恶性结节36例。早期及延迟SUVmax的AUC分别为0.719、0.816,差异有统计学意义,Z=2.356,P=0.039;恶性肺结节患者随访结果:死亡5例、转移3例、其余均健康。延迟SUVmax与患者生存状态存在相关性(X^2=18.1759,p<0.0001)。结论:肺结节延迟SUVmax较早期SUVmax诊断价值高,延迟SUVmax与患者的生存状态存在相关性。延迟SUVmax在肺结节诊断及恶性结节预后判断中有重要作用。AIM:To evaluate the value of delayed imaging of fluorodeoxyglucose positron emission computed tomography(18F-FDG PET/CT) in the diagnosis and prognosis of lung cancer. Methods: The clinical data of 44 patients with pulmonary nodules performed PET/CT scanning in Nantong Tumor Hospital from January 2013 to December 2014 were analyzed retrospectively. Early PET/CT imaging was performed 60 minutes after intravenous injection of 18F-FDG contrast medium, and delayed PET/CT imaging was performed 120 minutes later to determine the maximum standard uptake value(SUVmax) of the lesion in the two imaging. The area under the receptor operating characteristic curve(AUC)was used to analyze and compare the diagnostic efficacy of early and delayed SUVmax in the diagnosis of pulmonary nodules. One patient was followed up after anti-inflammatory treatment, 2 patients underwent lung biopsy and 41 patients underwent surgical and pathologic examination. The survival status(health, metastasis or death) of patients with malignant pulmonary nodules were followed up. Results:There were 8 cases of benign pulmonary nodules and 36 cases of malignant nodules. The AUC of early and delayed SUVmax was 0.719 and 0.816 respectively, and the difference was statistically significant(Z=2.356, P=0.039). Follow-up results of patients with malignant pulmonary nodules were 5 death, 3 metastasis, and the rest healthy. The values of delayed SUVmax correlated with the survival status(X^2=18.1759, P<0.0001). Conclusion:Delayed SUVmax is more valuable than early SUVmax in diagnosis of pulmonary nodules. Delayed SUVmax is associated with survival status of patients. Delayed SUVmax plays an important role in the diagnosis and prognostic estimation of malignant pulmonary nodules.

关 键 词：肺癌 正电子发射断层显像 延迟显像 诊断 预后 

分 类 号：R73[医药卫生—肿瘤]