JunD在浸润性乳腺癌分子亚型中的表达及意义  

Expression and Clinical Significance of JunD in Molecular Subtypes of Invasive Breast Carcinoma

作　　者：代新珍 米贤军[1] 钟守军[1] 段立锋[1] 杨伟洪[1] 刘祥玉[1] 徐秀梅[1] 黄兆华[1] DAI Xin-zhen;MI Xian-jun;ZHONG Shou-jun;DUAN Li-feng;YANG Wei-hong;LIU Xiang-yu;XU Xiu-mei;HUANG Zhao-hua(Department of Pathology,Zhongshan Boai Hospital,Zhongshan,Guangdong 528403,China)

机构地区：[1]中山市博爱医院病理科

出　　处：《中山大学学报（医学版）》2019年第6期946-952,共7页Journal of Sun Yat-Sen University:Medical Sciences

基　　金：中山市医学科研项目(2017J112)

摘　　要：【目的】分析JunD在浸润性乳腺癌分子亚型及乳腺良性恶性病变中的表达差异及临床意义。【方法】采用免疫组织化学SP法检测JunD在160例浸润性乳腺癌组织、191例乳腺增生组织及20例正常乳腺组织中的表达情况,分析JunD在浸润性乳腺癌分子亚型及乳腺增生性病变中的的表达差异及临床意义。【结果】①与其他分子亚型相比较,JunD在浸润性乳腺癌TNBC亚型中的表达水平明显升高(P<0.05),其他亚型之间两两比较差异无统计学意义(P>0.05)。②JunD在乳腺癌组织中的表达水平明显低于乳腺增生组织及正常乳腺组织(P<0.01)。③JunD在乳腺癌组织中的高表达率与低组织学分级相关(P<0.01),与肿物直径大小、年龄、淋巴结转移、ER、PR及临床分期无关(P>0.05)。【结论】JunD在浸润性乳腺癌TNBC亚型中显著高表达,有可能为TBNC亚型乳腺癌患者个性化靶向治疗提供一定方向;JunD在乳腺癌组织中的表达水平明显低于乳腺增生组织及正常乳腺组织,有利于乳腺良恶性病变的鉴别诊断。【Objective】To investigate the expression and clinical significance of JunD in molecular subtypes of inva?sive breast carcinoma,benign and malignant breast lesions.【Methods】Immunohistochemical examination was performed for 160 patients with invasive breast carcinoma,191 patients with breast intraductal proliferative lesions and 20 patients with normal breast tissue.【Results】①Comparison with other subtypes showed that the expression of JunD was significantly increased in TBNC subtype(P<0.05)and differences between other subtypes were not statistically significant(P>0.05).②The expression of JunD in invasive breast carcinoma was lower than that in breast intraductal proliferative lesions and normal breast tissue(P<0.01).③Based on immunohistochemical staining,high positive expression rate of JunD was associated with low histological grade(P<0.01).There is no correlation between JunD and tumor diameter,age,lymph nodes,ER,PR and histological grade(P>0.05).【Conclusions】The expression of JunD was significantly increased in TBNC subtype.To study the expression of JunD in TBNC subtype of invasive breast carcinoma may provide an evaluation in targeted treatment.The different expression of JunD in benign and malignant breast lesions may be helpful for their differential diagnosis.

关 键 词：浸润性乳腺癌 分子亚型 免疫组织化学 JUND 

分 类 号：R737.9[医药卫生—肿瘤]