幽门螺杆菌阴性消化性溃疡患者并发上消化道出血影响因素Logistic回归分析及防护策略  

Logistic Regression Analysis and Protective Strategy of Influencing Factors of Upper Gastrointestinal Bleeding in Patients with Helicobacter Pylori-negative Peptic Uulcer

作　　者：康利伟[1] 李雅琴 魏慧娜[1] KANG Li-wei;LI Ya-qin;WEI Hui-na(Department of Gastroenterology,Zhengzhou Second People's Hospital,Zhengzhou 450000)

机构地区：[1]河南省郑州市第二人民医院消化内科一病区

出　　处：《临床护理杂志》2019年第6期2-5,共4页Journal of Clinical Nursing

基　　金：河南省医学科技攻关计划项目(201709335)

摘　　要：目的探讨幽门螺杆菌(HP)阴性消化性溃疡(PU)患者并发上消化道出血的影响因素及防护策略。方法分析我院收治的608例PU患者的上消化道出血和HP感染情况,对181例HP阴性的PU患者并发上消化道出血的相关危险因素进行单因素分析和多因素非条件Logistic回归分析,给予患者防护策略指导。结果608例PU患者中HP阴性181例(29.77%);HP阴性的PU患者并发上消化道出血占39.45%,显著高于单纯PU的患者(22.73%)(P<0.05);单因素分析结果显示,近一周内饮入酒精量≥500ml、出现腹痛、长期服用非甾体抗炎药、溃疡数量、凝血功能异常、血小板计数<10×109/L的患者并发上消化道出血发生率显著高于未并发上消化道出血患者(P<0.05);Logistic回归分析结果显示,近一周内饮入酒精量≥500ml、出现腹痛、长期服用非甾体抗炎药、凝血功能异常、血小板计数<10×109/L为其独立风险因素。结论近一周内饮入酒精量≥500ml、出现腹痛、长期服用非甾体抗炎药、凝血功能异常、血小板计数<10×109/L是HP阴性PU患者并发上消化道出血的危险因素,应针对上述因素,指导患者保持良好的生活方式,加强健康教育宣教。Objective To investigate the factors and protective strategies of upper gastrointestinal bleeding in patients with Hp negative peptic ulcer(PU).Methods To diagnose and analyze the upper gastrointestinal hemorrhage and Helicobacter pylori infection in 608 patients with PU admitted to our hospital.Univary analysis and multi-factor non-conditions Logistic regression analysis for risk factors was given to in 181 HP-negative PU patients associated with upper gastrointestinal bleeding.Give the patient protection strategy guidance.Results Among 608 patients with PU,HP was negative in 181 cases 29.77%.HP-negative PU patients with concurrent upper gastrointestinal hemorrhage accounted for 39.45%,significantly higher than patients with simple PU 22.73%(P<0.05);The results of the single factor analysis showed that the incidence of upper gastrointestinal bleeding in patients who had alcohol intake≥500ml in the past week,abdominal pain,long-term use of non-steroidal anti-inflammatory drugs,number of ulcers,abnormal coagulation function,and platelet count<10×109/L was significantly higher than that of patients without concurrent upper gastrointestinal hemorrhage(P<0.05);Logistic regression results show that alcohol intake≥500ml in the past week,abdominal pain,long-term use of non-steroidal anti-inflammatory drugs,abnormal coagulation function,platelet count<10×109/L are its independent risk factor.Conclusion Alcohol consumption≥500ml in the past week,abdominal pain,long-term use of non-steroidal anti-inflammatory drugs,abnormal blood coagulation,platelet count<10×109/L is a risk factor for upper gastrointestinal bleeding in HP-negative PU patients.According to the above factors,patients should be guided to maintain a good lifestyle and strengthen health education.

关 键 词：幽门螺杆菌阴性 消化性溃疡 上消化道出血 

分 类 号：R573.1[医药卫生—消化系统] R573.2[医药卫生—内科学]