水产动物TGF-β超家族基因系统进化及生物学功能研究进展  

A review of TGF-β superfamily genes in aquatic animals: phylogeny and biological functions

作　　者：李莹莹 崔东遥 程操 孙景贤[1] 李丹彤[1] 李家祥[1] 常亚青[1] 湛垚垚[1] LI Ying-ying;CUI Dong-yao;CHENG Cao;SUN Jing-xian;LI Dan-tong;LI Jia-xiang;CHANG Ya-qing;ZHAN Yao-yao(Key Laboratory of Mariculture&Stock Enhancement in North China's Sea,Ministry of Agriculture and Rural Affairs,Dalian Ocean University,Dalian 116023,China)

机构地区：[1]大连海洋大学农业农村部北方海水增养殖重点实验室

出　　处：《大连海洋大学学报》2019年第6期853-862,共10页Journal of Dalian Ocean University

基　　金：辽宁省自然科学基金资助项目(20170540104);国家自然科学基金资助项目(31672652);农业农村部农业科研人才及其创新团队项目

摘　　要：转化生长因子-β(Transforming growth factor-β,TGF-β)超家族是一类普遍存在于真核生物中的调控型细胞因子,其家族成员众多,按照其序列结构特征和生物学功能的不同,主要分为TGF-β亚家族、DVR(Decapentaplegic/vg-1-related)亚家族、激活素(Activin)/抑制素(Inhibin)亚家族及其他亚家族等。大量研究显示,TGF-β蛋白超家族成员可调控细胞外基质合成、胚胎发育、器官形成、骨骼再生、组织损伤修复、机体免疫及肿瘤发生等多种生理生化过程。近年来,TGF-β超家族成员在调控水产动物细胞分化、胚胎发育、骨骼形成及免疫应答等生理生化过程中的作用受到人们的广泛关注,本文中综述了近年来水产动物TGF-β超家族成员的系统进化及生物学功能研究进展,为全面系统地了解和掌握该家族成员在水产动物繁殖、发育、生理生化及病理响应等过程中的作用提供线索和参考资料。The transforming growth factor-β(TGF-β)as a large superfamily containing more than 40 members in eukaryotic cells can be classified into four sub-families including TGF-β,DVR,Activin/Inhibin and others according to their sequence characterizations and bio-functions.It has been well documented that TGF-βplays vital roles in various physiological processes of organisms,including cellular reactions,embryonic development,organogenesis,bone regeneration,tissue repair and immune system.Recently,it is widely paid attention that the role of TGF-βin cell differentiation,embryonic and cytoskeleton development and innate immune responses in aquatic animals.Here we reviewed the research progress of phylogeny and biological functions of TGF-βsuperfamily in aquatic animals and provided a reference for better understanding of the role of TGF-βsuperfamily members in the progress of reproduction,development,physiological and biochemical in aquatic animals systematically.

关 键 词：TGF-Β 水产动物 系统进化 生物学功能 

分 类 号：Q74[生物学—分子生物学]