DNA甲基化在结直肠癌和肺癌诊疗中的研究进展  

Progress of DNA methylation in the diagnosis and treatment of colorectal and lung cancer research

作　　者：雷旦生[1] 喻晶[1] Lei Dansheng;Yu Jing(Department of Laboratory,Hubei Cancer Hospital,Hubei Clinical Research Center of Colorectal Cancer,Wuhan Clinical Research Center of Colorectal Cancer,Wuhan 430079,China)

机构地区：[1]湖北省肿瘤医院检验科,湖北省结直肠癌临床医学研究中心,武汉市结直肠癌临床医学研究中心,武汉430079

出　　处：《中华检验医学杂志》2019年第11期976-980,共5页Chinese Journal of Laboratory Medicine

基　　金：湖北省卫计委面上项目(WJ2017M143);湖北省自然科学基金指导性项目(2017CFC826)。

摘　　要：结直肠癌和肺癌均是目前中国发病率和病死率持续攀升的恶性肿瘤,治疗效果均不尽人意。随着表观遗传学的发展,近些年DNA甲基化在肿瘤的发生发展机制、早期诊断和治疗方面取得了一系列非常有应用前景的研究成果,全面认识其现状和进展对于个体化精准医疗具有重大意义。本文旨在概述DNA甲基化在结直肠癌和肺癌诊疗中的研究和应用进展,并展望了未来发展方向。The incidences of colorectal and lung cancer are both increased in China while the treatment effect is far from satisfactory.As the rapid progress of epigenetic studies,DNA methylation has a series of promising research results in the pathogenesis,early diagnosis and treatment of tumor.A comprehensive understanding of its development status and existing problems is of great significance for the future research and the implementation of precision medicine.Herein,the aim is to outline the progress of DNA methylation in Colorectal and lung cancer and make a prospect for the future research.

关 键 词：结直肠肿瘤 肺肿瘤 DNA甲基化 早期诊断 治疗结果 预后 

分 类 号：R73[医药卫生—肿瘤]