长链非编码RNA在缺血性脑卒中的研究进展  

Advances of long-chain non-coding RNAs in ischemic stroke

作　　者：于诗嘉[1] 于明军[2] 何平平[1] 冯娟[1] Yu Shijia;Yu Mingjun;He Pingping;Feng Juan(Department of Neurology,Shengjing Hospital,China Medical University,Shenyang 110004,China;Department of Neurosurgery,Shengjing Hospital,China Medical University,Shenyang 110004,China)

机构地区：[1]中国医科大学附属盛京医院神经内科,沈阳110004 [2]中国医科大学附属盛京医院神经外科,沈阳110004

出　　处：《神经疾病与精神卫生》2019年第8期814-818,共5页Journal of Neuroscience and Mental Health

基　　金：国家自然科学基金面上项目(81771271);辽宁省自然科学基金计划项目(20180550913)。

摘　　要：缺血性脑卒中是目前影响人类健康,威胁人类生命的主要疾病之一,目前该病已受到越来越多的关注.长链非编码RNA(lncRNA)作为基因组中的调节基因具有非常复杂的生物学功能,可以参与多种细胞生物活动环节,包括染色质重塑、mRNA可变性剪接、mRNA降解和蛋白质的翻译等.目前已发现诸多lncRNA在肿瘤、心血管疾病及神经退行性疾病的发生和发展等过程中发挥重要作用,但是有关lncRNA与缺血性脑血管病的研究还很有限.现就lncRNA与缺血性卒中的研究进展作一综述.Ischemic stroke is one of the major diseases affecting human health and threatening human life.At present,the disease has been attracting more and more attention.As a regulatory gene in genome,long non-coding RNA(LncRNA)has very complex biological functions and plays important roles in many stages of cell biological activity,including mediating chromatin remodeling,mRNA alternative splicing,mRNA degradation and protein translation.Up to now,a variety of lncRNAs have been found to play an important role in the occurrence and development of cancers,cardiovascular diseases and neurodegenerative diseases.However,the researches on lncRNAs and ischemic cerebrovascular diseases are still limited.Therefore,this review mainly outlines research progresses between lncRNA and ischemic stroke.

关 键 词：长链非编码RNA 转录调控 缺血性脑卒中 综述 

分 类 号：R73[医药卫生—肿瘤]