伽玛刀联合肝动脉栓塞化疗治疗原发性肝癌的临床研究  

Clinical study of gamma knife combined with transcatheter arterial chemoembolization in the treatment of primary liver cancer

作　　者：罗晓蓉[1] 宋长龙[2] 汪金锋[2] 张军[2] 李腾庆[1] 刘华强[2] 李绮云[2] 张宗平[2] LUO Xiaorong;SONG Changlong;WANG Jinfeng;ZHANG Jun;LI Tengqing;LIU Huaqiang;LI Qiyun;ZHANG Zongping(Department of Gastroenterology of Guangdong Agricultural Reclamation Center Hospital,Zhanjiang 524001,China;Gamma Knife Treatment Area of Guangdong Agricultural Reclamation Center Hospital,Zhanjiang 524001,China)

机构地区：[1]广东省农垦中心医院内一科,湛江524001 [2]广东省农垦中心医院伽玛刀治疗区,湛江524001

出　　处：《广州医药》2019年第6期47-50,共4页Guangzhou Medical Journal

基　　金：国家十三五项目重点研发计划(2017YFC0113700);湛江市科技专项(170509091680387)

摘　　要：目的观察伽玛刀联合肝动脉栓塞化疗治疗原发性肝癌的临床疗效及安全性。方法选取2017年1月—2017年12月期间,广东省农垦中心医院收治的76例原发性肝癌患者作为研究对象,随机分为对照组和观察组,每组各38例。对照组患者采用肝动脉栓塞化疗术进行治疗,观察组患者采用伽玛刀联合肝动脉栓塞化疗术进行治疗。对比两组患者近期临床疗效、18个月实际生存率、不良反应发生情况和治疗前后甲胎蛋白(AFP)水平。结果治疗结束3个月时,观察组患者客观缓解率(ORR)和疾病控制率(DCR)均高于对照组,差异有统计学意义(P<0.05);两组患者治疗后AFP水平均低于治疗前,且观察组患者AFP水平低于对照组,差异均有统计学意义(P<0.05);两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。观察组患者18个月实际生存率高于对照组,差异有统计学意义(P<0.05)。结论伽玛刀联合肝动脉栓塞化疗治疗原发性肝癌的临床疗效确切,且具有较好的安全性。Objective To observe the clinical efficacy and safety of gamma knife combined with transcatheter arterial chemoembolization in the treatment of liver cancer.Methods From January 2017 to December 2017,76 patients with primary liver cancer in Guangdong Provincial Reclamation Center Hospital were randomly divided into the control group and the observation group,with 38 cases in each group.Patients in the control group were treated with transcatheter arterial chemoembolization.Patients in the observation group were treated with Gamma Knife combined with transcatheter arterial chemoembolization.The recent clinical efficacy,18-month actual survival rate,adverse reaction and alpha-fetoprotein(AFP)levels after treatment were compared between the two groups.Results At the end of 3 months of treatment,the objective response rate(ORR)and disease control rate(DCR)of the observation group were higher than the control group,the difference was statistically significant(P<0.05).The AFP levels in the two groups were lower than those before treatment,and the AFP level in the observation group was lower than that in the control group,the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).The 18-month actual survival rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).Conclusion Gamma knife combined with transcatheter arterial chemoembolization for the treatment of primary liver cancer is clinically effective and safe.

关 键 词：伽玛刀 肝动脉栓塞 原发性肝癌 疗效 安全性 

分 类 号：R73[医药卫生—肿瘤]