血管内介入疗法治疗急性缺血性脑卒中患者的疗效及对血液流变学和炎性因子的影响  

Therapeutic effects of endovascular interventional therapy on acute ischemic cerebral stroke and its effect on hemorheology and inflammatory factors of patients

作　　者：宋贺[1] 刘存华 李健 苏现辉[1] 张金峰[1] SONG He;LIU Cunhua;LI Jian(Department of ICU of Neurology,The First Hospital of Shijiazhuang,Hebei,Shijiazhuang 050011,China)

机构地区：[1]河北省石家庄市第一医院神经外科,050011 [2]河北省正定县人民医院急诊科

出　　处：《河北医药》2019年第23期3609-3612,共4页Hebei Medical Journal

基　　金：石家庄市科学技术研究与发展计划项目(编号:171792083)

摘　　要：目的探究血管内介入疗法对急性缺血性脑卒中患者的临床疗效及对血液流变学和炎性因子的影响。方法选取2017年8月至2019年1月收治的行血管内介入治疗的急性缺血性脑卒中患者50例为试验组,另选取同期接受药物静脉溶栓治疗的急性缺血性脑卒中患者50例为对照组。比较2组临床疗效和高切黏度、低切黏度、血浆比黏度、红细胞比容等血液流变学指标水平及C-反应蛋白(CRP)、白细胞介素6(IL-6)、肿瘤坏死因子α(TNF-α)等炎性因子指标水平。结果对照组临床治疗总有效率为84.00%(42/50),试验组临床治疗总有效率为96.00%(48/50),试验组高于对照组,差异有统计学意义(P<0.05)。溶栓前,2组高切黏度、低切黏度、血浆比黏度、红细胞比容水平比较,差异无统计学意义(P>0.05);溶栓1周后,2组高切黏度、低切黏度、血浆比黏度和红细胞比容水平均低于溶栓前,并且试验组低于对照组,差异有统计学意义(P<0.05)。溶栓前,2组CRP、IL-6和TNF-α水平比较,差异无统计学意义(P>0.05);溶栓1周后,2组CRP、IL-6和TNF-α水平均低于溶栓前,同时试验组低于对照组,差异有统计学意义(P<0.05)。结论血管内介入疗法应用在急性缺血性脑卒中患者治疗中疗效确切,有利于改善患者血液流变学状态,抑制炎性介质反应,值得临床推广应用。Objective To investigate the therapeutic effects of endovascular interventional therapy on acute ischemic cerebral stroke and its effect on hemorheology and inflammatory factors of patients.Methods A total of 50 patients with acute ischemic stroke who were admitted and treated by intravascular interventional therapy in our hospital from August 2017 to January 2019 were enrolled as experimental group,at the same time,the other 50 patients with acute ischemic stroke who were treated by intravenous thrombolysis were enrolled as control group.The clinical efficacy and hemorheological indexes including high incisions viscosity,low incisions viscosity,plasma specific viscosity,erythrocyte volume,as well as inflammatory factors including C reactive protein(CRP),interleukin 6(IL-6),tumor necrosis factor alpha(TNF-α)were observed and compared between the two groups.Results The total effective rate in experimental group was 96.00%(48/50),which was significantly higher than that[84.00%(42/50)]in control group(P<0.05).Before thrombolysis,there were no statistically significant differences in high viscosity,low viscosity,plasma specific viscosity and erythrocyte specific volume between the two groups(P>0.05).At 1 week after thrombolysis,the high viscosity,low viscosity,plasma specific viscosity and erythrocyte specific capacity in both groups were lower than those before thrombolysis,moreover,which in experimental group were significantly lower than those in control group(P<0.05).Before thrombolysis,there were no statistically significant differences in the levels of CRP,IL-6 and TNF-αbetween the two groups(P>0.05).At 1 week after thrombolysis,the the levels of CRP,IL-6 and TNF-αin both groups were lower than those before thrombolysis,moreover,which in experimental group were significantly lower than those in control group(P<0.05).Conclusion The application of endovascular interventional therapy in treatment of acute ischemic stroke has definite therapeutic effects,which is conducive to improving the hemorheology of patien

关 键 词：血管内介入疗法 急性缺血性脑卒中 疗效 血液流变学 炎性因子 

分 类 号：R743.33[医药卫生—神经病学与精神病学]