血浆可溶性髓样细胞触发受体1对成人脓毒症患者诊断价值的Meta分析  

Diagnostic value of plasma soluble triggering receptor expressed on myeloid cells-1 for adult patients with sepsis: a meta-analysis

作　　者：张洪齐 赵华英 杨超[3] 孔令文 卢仁福 吴庆琛[1] 都定元 Zhang Hongqi;Zhao Huaying;Yang Chao;Kong Lingwen;Lu Renfu;Wu Qingchen;Du Dingyuan(Department of Cardiothoracic Surgery,the First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China;Department of Gastroenterology,the First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China;Department of Burn and Plastic Surgery,the First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China;Department of Cardiothoracic Surgery,Central Hospital of Chongqing University,Chongqing Emergency Medical Center,Chongqing 400014,China)

机构地区：[1]重庆医科大学附属第一医院胸心外科,重庆4000161 [2]重庆医科大学附属第一医院消化内科,重庆4000161 [3]重庆医科大学附属第一医院烧伤整形科,重庆4000161 [4]重庆大学附属中心医院、重庆市急救医疗中心胸心外科,重庆400014

出　　处：《中华危重症医学杂志（电子版）》2019年第5期328-334,共7页Chinese Journal of Critical Care Medicine:Electronic Edition

基　　金：国家“十二五”科技支撑计划资助项目（2012BAI11B01）;重庆市科委自然科学基金（重点）资助项目（CSTC2012jjB10021）;重庆市卫生局医学科学技术研究重点资助项目（2010-1-52、2011-2-378）

摘　　要：目的评价血浆可溶性髓样细胞触发受体1(sTREM-1)对成人脓毒症患者的诊断价值。方法检索PubMed、Embase、Cochrane图书馆、中国生物医学文献数据库(CBM)、中国期刊全文数据库(CNKI)、万方数据库和中文科技期刊全文库(VIP)数据库从建库至2017年5月发表的有关血浆sTREM-1对成人脓毒症患者诊断价值的文献。采用双变量模型计算合并诊断比值比(DOR)、合并敏感度、合并特异度、合并阳性似然比(PLR)及合并阴性似然比(NLR)。进行合并受试者工作特征(SROC)曲线,获得曲线下面积(AUC)。结果最终纳入30篇文献,共3349例患者。Meta分析显示,合并DOR为20.03[95%置信区间(CI)(12.20,32.87)]、合并敏感度为0.82[95%CI(0.77,0.86)]、合并特异度为0.81[95%CI(0.76,0.85)]、合并PLR为4.36[95%CI(3.37,5.64)]、合并NLR为0.22[95%CI(0.16,0.29)]。SROC曲线显示合并AUC为0.89[95%CI(0.85,0.91)]。结论血浆sTREM-1对诊断成人脓毒症患者具有中度诊断价值。Objective To investigate the diagnostic value of plasma soluble triggering receptor expressed on myeloid cells-1(sTREM-1)as a biomarker for adult patients with sepsis.Methods Related studies on the diagnostic value of plasma sTREM-1 in adult patients with sepsis were searched in PubMed,Embase,Cochrane,CBM,CNKI,Wangfang and VIP published up to May 2017.The bivariate model was used to calculate the pooled diagnostic odds ratio(DOR),pooled sensitivity,pooled specificity,pooled positive likelihood ratio(PLR),and pooled negative likelihood ratio(NLR).The area under the summary receiver operating characteristic(SROC)curve was analyzed.Results Thirty eligible articles involving 3349 patients were included.Meta-analysis in total population showed that the pooled DOR was 20.03[95%confidence interval(CI)(12.20,32.87)];the pooled sensitivity was 0.82[95%CI(0.77,0.86)];the pooled specificity was 0.81[95%CI(0.76,0.85)];the pooled PLR was 4.36[95%CI(3.37,5.64)];the pooled NLR was 0.22[95%CI(0.16,0.29)].The SROC curve showed that the pooled AUC was 0.89[95%CI(0.85,0.91)].Conclusion Plasma sTREM-1 has a moderate value in the diagnosis of adult patients with sepsis.

关 键 词：可溶性髓样细胞触发受体1 脓毒症 诊断 META分析 

分 类 号：R73[医药卫生—肿瘤]