原发性颌骨骨内鳞状细胞癌的预后相关因素分析  

Prognostic Factors of Primary Intraosseous Squamous Cell Carcinoma of the Jaw

作　　者：郭凌燕[1] 陈芬[1] 吴平凡[1] 李羽[1] 雷振革 陈林林[1] GUO Lingyan;CHEN Fen;WU Pingfan;LI Yu;LEI Zhengge;CHEN Linlin(Department of Oral and Maxillofacial Surgery,Affiliated Stomatological Hospital of Nanchang University,The Key Laboratory of Oral Biomedicine in Jiangxi Province,Nanchang 330006,China)

机构地区：[1]南昌大学附属口腔医院口腔颌面外科江西省口腔生物医学重点实验室

出　　处：《口腔医学研究》2019年第12期1132-1136,共5页Journal of Oral Science Research

摘　　要：目的:探讨影响原发性颌骨骨内鳞状细胞癌(primary intraosseous squamous cell carcinoma PIOSCC)预后的相关因素。方法:选择南昌大学附属口腔医院口腔颌面外科(2012~2018年)收治的PIOSCC患者作为研究对象,收集患者的临床、影像学及组织病理学资料,并进行随访,采用描述性统计学方法,分析影响该疾病预后的相关因素。结果:本研究共纳入21例PIOSCC患者,平均诊断年龄为53.7岁(41~77岁)。其中,男性13例,女性8例。上颌骨8例,下颌骨13例。在随访期间,2例死于局部复发,5例死于远处转移,总生存率为66.7%。肿瘤大小、颈淋巴结转移和TNM临床分期是影响该疾病预后的重要因素。结论:大于4 cm的肿瘤或出现颈淋巴结转移的PIOSCC患者预后较差。Objective:To determine the prognostic factors of primary intraosseous squamous cell carcinoma(PIOSCC)of the jaw.Methods:Patients with PIOSCC of the jaw admitted to the Department of Oral and Maxillofacial Surgery,Affiliated Stomatological Hospital of Nanchang University(2012-2018)were selected as the study subjects.The clinical,radiological,and histopathological data of these patients were collected and followed up.Descriptive statistical analysis was used to determine the prognostic factors of the disease.Results:A total of 21 PIOSCC patients were included in this study.The mean age at diagnosis was 53.7 years(ranged from 41 to 77 years).Of the 21 patients,there were 13 males and 8 females,and 8 cases in maxilla and 13 cases in mandible.During the follow-up period,2 cases were died of local recurrence and 5 cases were died of distant metastasis.The overall survival rate was 66.7%.Tumor size,cervical lymph node metastasis,and clinical stage of TNM were the negative prognostic factors.Conclusion:The prognosis of patients is poor if the tumor is more than 4 cm in size or with cervical lymph node metastasis.

关 键 词：原发性骨内鳞状细胞癌 预后 

分 类 号：R73[医药卫生—肿瘤]