All-in-one theranostic nanoplatfbrm with controlled drug release and activated MRI tracking functions for synergistic NIR-II hyperthermiachemotherapyof tumors  

作　　者：Xianguang Ding Haitao Zhao Chunyan Li Qiangbin Wang Jiang Jiang 

机构地区：[1]i-Lab and Division of Nanobiomedicine,CAS Key Laboratory of Nano-Bio Interface,CAS Center for Excellence in Nanoscience,Suzhou Institute of Nano-Tech and Nano-Bionics,Chinese Academy of Sciences,Suzhou 215123,China [2]Institute for Health Innovation and Technology,National University of Singapore,Singapore 117599,Singapore [3]School of Nano Technology and Nano Bionics,University of Science and Technology of China,Hefei 230026,China

出　　处：《Nano Research》2019年第12期2971-2981,共11页纳米研究（英文版）

基　　金：This work was funded by the National Natural Science Foundation of China(No.21473243);Six Talent Peaks Project in Jiangsu Province(No.SWYY-243).

摘　　要：Real-time tracking drug release behavior is fundamentally important for avoiding adverse effects or unsuccessful treatment in personalizemedical treatment.However,the development of a non-invasive drug reporting platform still remains challenging.Herein the design of a novelsyn thetic magnetic resonance imaging(MRI)agent for drug release tracking(SMART)is reported,which integrates photothermal core andparamagnetic ion/drug loading shell with a thermal valve in a hybrid structure.Through near-infrared(NIR)-II photothermal effect originatingfrom inner Au-Cu9S5 nanohybrid core,burst release of drugs loaded in the mesoporous silica shell is achieved.The concomitant use of aphase change material not only prevents premature drug release,but also regulates heating effect,keeping local temperature below 45℃,enabling synergistic chemotherapy and mild hyperthermia in vitro and in vivo.Furthermore,the drug release from SMART facilitates protonaccessibility to the paramagnetic ions anchored inside mesopores channels,enhancing Iongitudinal T1 relaxation rate and displaying positivesignal correlation to the amount of released drug,thus allowing norvinvasive real-time monitoring of drug release event.The current studyhighlights the potential of designed MRI nanophores such as SMART for real-time and in-situ monitoring of drug delivery for precisionthera nostic applications.

关 键 词：HYPERTHERMIA magnetic resonance near-infrared(NIR)-II window drug delivery chemotherapy 

分 类 号：R73[医药卫生—肿瘤]