5例腹膜胶质瘤病的临床病理观察  

Peritoneal gliomatosis: Clinicopathologic analysis of 5 cases

作　　者：温文娟[1] 尹艳华[1] 李迎雪[1] 姚志刚[2] 郑正 樊延延[1] 张学东[1] WEN Wen-juɑn;YIN Yɑn-huɑ;LI Yinɡ-xue;YAO Zhi-ɡɑnɡ;ZHENG Zhenɡ;FAN Yɑn-yɑn;ZHANG Xue-donɡ(Department of Pathology,Liaocheng People’s Hospital,Liɑochenɡ252000,China;Department of Pathology,Shandong Provincial Hospital)

机构地区：[1]聊城市人民医院病理科,山东聊城252200 [2]山东省立医院病理科,山东济南250021

出　　处：《诊断病理学杂志》2019年第11期744-748,共5页Chinese Journal of Diagnostic Pathology

摘　　要：目的探讨腹膜胶质瘤病(GP)的发生、临床病理特征、起源及预后。方法对5例GP进行相关临床资料、组织形态学及免疫组化分析,并复习国内外相关文献。结果患者年龄18~34岁。卵巢未成熟畸胎瘤(Immature teratoma of ovary)WHOⅠ级1例、WHOⅡ级4例。2例GP发生于卵巢未成熟畸胎瘤术后化疗后;1例于卵巢未成熟畸胎瘤术后16天确诊;2例与卵巢未成熟畸胎瘤手术时同时发现。GP于显微镜下表现为多个成熟性神经胶质结节存在于腹膜内及盆腹腔脏器表面,1例同时伴发腹膜成熟性畸胎瘤。免疫组化标记GFAP、S100及SOX2阳性,OCT3/4及SALL4阴性表达。术后5例均采取辅助化疗,随访12~106个月,3例健康生存,2例失访。结论GP是一种罕见疾病,可以纤维化、长期存在、复发、恶变或作为其他肿瘤一部分,需长期随访。组织起源需要进一步遗传及分子生物学研究。Purpose To investigate the occurrence,clinicopathological features,origin and prognosis of peritoneal gliomatosis(GP).Methods The clinical data,histomorphology and immunohistochemistry of 5 cases of GP were analyzed,and the related literatures were reviewed.Results The age of the patients ranged from 18 to 34 years.Immature teratoma of ovary included WHO grade I in 1 case and WHO grade II in 4 cases.GP occurred in 2 cases of ovarian immature teratoma after operation and chemotherapy,1 case was diagnosed 16 days after the operation of ovarian immature teratoma.and 2 cases were found simultaneously with ovarian immature teratoma during operation.Microscopically,GP showed multiple mature glial nodules in the peritoneum and on the surface of pelvic and abdominal organs.One case was accompanied by peritoneal mature teratoma.Immunohistochemical markers such as GFAP,S100 and SOX2 were positive,while OCT3/4 and SALL4 were negative.After operation,5 cases were treated with adjuvant chemotherapy.Follow-up ranged from 12 to 106 months.3 cases survived and 2 cases were lost.Conclusion GP is a rare disease which can be fibrosis,long-term existence,recurrence,malignant transformation or as part of other tumors,and needs long-term follow-up.The origin of tissues requires further genetic and molecular biology studies.

关 键 词：腹膜胶质瘤病(GP) 卵巢未成熟畸胎 畸胎瘤继续生长综合征(GTS) GP起源 预后 

分 类 号：R735.5[医药卫生—肿瘤]