线粒体DNA在中性粒细胞胞外诱捕网中作用的研究进展  

Research progress on the role of mitochondrial DNA in the neutrophil extracellular traps

作　　者：张穗盈 李楠[1] 邓育琼 程喜平[1] Zhang Suiying;Li Nan;Deng Yuqiong;Cheng Xiping(Department of Dermatology,the First Affiliated Hospital of Guangzhou Medical University,Guangzhou 510120,China)

机构地区：[1]广州医科大学附属第一医院皮肤科,510120

出　　处：《国际免疫学杂志》2019年第6期603-607,共5页International Journal of Immunology

基　　金：国家自然科学基金面上项目(81373649,81673983);广东省自然科学基金面上项目(2014A030313504)。

摘　　要：中性粒细胞胞外诱捕网(neutrophil extracellular traps,NETs)是近十余年发现的新的细胞程序性死亡方式,其来源、构成及作用等已成为目前的研究热点.最新研究表明,线粒体DNA(mitochon-drial DNA,mtDNA)是NETs的组成部分,在线粒体氧化呼吸产生大量活性氧(reactive oxygen species,ROS)的情况下,氧化异常的mtDNA与NETs相互激活,参与多种疾病的发生.以下就NETs的研究进展、mtDNA在NETs中的作用及可能的关系进行综述.Neutrophil extracellular traps(NETs)is a new programmed cell death,which is nearly found more than 10 years with its source,composition and function has become the hotspot research.Recent studies have shown that mitochondrial DNA(mtDNA)is part of NETs.In the case of Large quantity of ROS generated by mitochondrial oxidative respiration,mtDNA with abnormal oxidation and NETs are activated each other and participate in the occurrence of a variety of diseases.This paper reviews the research progress of NETs,the role of mtDNA in NETs and its possible relationship.

关 键 词：线粒体DNA 中性粒细胞胞外诱捕网 细胞程序性死亡 活性氧 红斑狼疮 

分 类 号：R73[医药卫生—肿瘤]